Statistical analysis of quality of life with missing data in cancer clinical trials

Andrea B. Troxel*, Diane L. Fairclough, Desmond Curran, Elizabeth A. Hahn

*Corresponding author for this work

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

We summarize issues that arise when considering quality of life (QOL) data in cancer clinical trials, especially those related to missing data. We describe different types of missing data mechanisms, and discuss ways of assessing and testing missing data mechanisms. A section on presentation of study design and results describes how graphical displays can effectively document the extent of the missing data problem, as well as describe its impact on interpretation of results. Finally, we describe several different statistical methods used to analyse repeated measures, with an emphasis on their properties and their ability to adequately handle different types of missing data mechanisms. We make recommendations as to the most appropriate methods, and suggest important directions for future research.

Original languageEnglish (US)
Pages (from-to)653-666
Number of pages14
JournalStatistics in Medicine
Volume17
Issue number5-7
StatePublished - Mar 15 1998

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Missing Data Mechanism
Quality of Life
Missing Data
Clinical Trials
Statistical Analysis
Cancer
Graphical Display
Neoplasms
Repeated Measures
Statistical method
Recommendations
Testing
Direction compound

ASJC Scopus subject areas

  • Epidemiology

Cite this

Troxel, Andrea B. ; Fairclough, Diane L. ; Curran, Desmond ; Hahn, Elizabeth A. / Statistical analysis of quality of life with missing data in cancer clinical trials. In: Statistics in Medicine. 1998 ; Vol. 17, No. 5-7. pp. 653-666.
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Troxel, AB, Fairclough, DL, Curran, D & Hahn, EA 1998, 'Statistical analysis of quality of life with missing data in cancer clinical trials', Statistics in Medicine, vol. 17, no. 5-7, pp. 653-666.

Statistical analysis of quality of life with missing data in cancer clinical trials. / Troxel, Andrea B.; Fairclough, Diane L.; Curran, Desmond; Hahn, Elizabeth A.

In: Statistics in Medicine, Vol. 17, No. 5-7, 15.03.1998, p. 653-666.

Research output: Contribution to journalArticle

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