Status asthmaticus: Strategies for stabilization after intubation

Manu Jain*, T. Corbridge

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


For patients with status asthmaticus that is refractory to drugs, mechanical ventilation helps prevent cardiac and cerebral complications. The decision to intubate often is based on the clinician's assessment of impending cardiopulmonary arrest. We recommend rapid-sequence induction using a large-diameter oral endotracheal tube. To minimize dynamic hyperinflation of the lung during ventilation, start with the following ventilator settings: respiratory rate, 12 to 14 breaths per minute; tidal volume, 7 to 8 mL/kg; inspiratory flow rate, 80 L/min; and no positive end-expiratory pressure. Maintain single-breath plateau pressure at less than 30 cm H2O by adjusting minute ventilation as appropriate. Sedation and analgesia are indicated for all patients during ventilation; propofol (or a benzodiazepine) combined with an opioid is a good choice. Consider short-term paralysis when sedation is insufficient.

Original languageEnglish (US)
Pages (from-to)330-338
Number of pages9
JournalJournal of Critical Illness
Issue number6
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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