Status spongiosus resulting from intracerebral infection of mice with temperature sensitive mutants of vesicular stomatitis virus

Mauro Carlo Dal Canto, S. G. Rabinowitz, T. C. Johnson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Mice infected intracerebrally (i.c.) with wild type (wt) VSV or temperature sensitive (ts) mutants, ts 11, ts 22, ts 31 and ts 41, were studied for the development of histopathologic lesions in the central nervous system (CNS). Mice infected i.c. with wt VSV exhibited histopathologic lesions consisting principally of occasional foci of perivascular mononuclear cell infiltration and rare foci of necrosis. All wt VSV infected mice died within 2 days of i.c. inoculation. In contrast, mice infected i.c. with ts 22 and ts 31 developed spongiform lesions limited to the grey matter of the spinal cord beginning 4 days after inoculation. The spongiform lesions rapidly spread to involve the entire grey matter of the spinal cord by 5-7 days after infection. Vacuolar changes were restricted principally to neuronal processes and astrocytes. Ts 22 and ts 31 infected mice developed neurologic illness beginning 4 days after infection and the majority of mice died by 7 days after infection. Mice infected with ts 11 and ts 41, on the other hand, remained clinically well and were devoid of neuro pathologic lesions at 4 and 8 days after infection.

Original languageEnglish (US)
Pages (from-to)321-330
Number of pages10
JournalBritish Journal of Experimental Pathology
Volume57
Issue number3
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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