Abstract
Initial studies of multiple-agent antiretroviral combinations including the thymidine nucleoside analogue reverse transcriptase inhibitor (RTI) stavudine (2',3'-didehydro-2',3'-dideoxythymidine; D4T) have shown potent anti-HIV effects in both treatment-naive and -experienced patients. A number of ongoing randomized comparative trials are assessing stavudine-based multiple agent combinations, including protease inhibitor-containing and -sparing regimens, triple nucleoside RTI regimens and regimens including non-nucleoside RTIs and/or hydroxyurea as initial or subsequent therapy. Results of these studies should help to define additional first-line treatment options and strategies for sequencing antiretroviral treatment regimens.
Original language | English (US) |
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Pages (from-to) | 69-73 |
Number of pages | 5 |
Journal | Antiviral Therapy |
Volume | 3 |
Issue number | SUPPL. 4 |
State | Published - Dec 23 1998 |
ASJC Scopus subject areas
- Pharmacology