Stem Cell Therapy in Single-Ventricle Physiology: Recent Progress and Future Directions

Mohamed Abdullah, Samantha Kegel, Muthukumar Gunasekaran, Progyaparamita Saha, Xuebin Fu, Rachana Mishra, Sudhish Sharma, Kaushal Sunjay Kaushal*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Current surgical and medical treatment options for single ventricle physiology conditions remain palliative. On the long term, despite treatment, the systemic ventricle has a significant risk of developing failure. There are unmet needs to develop novel treatment modalities to help ameliorate the ventricular dysfunction. Advances in the field of stem cell therapy have been promising for the treatment of heart failure. Numerous stem cell populations have been identified. Preclinical studies in small and large animal models provide evidence for effectiveness of this treatment modality and reveal several mechanisms of action by which stem cells exert their effect. Many clinical trials have been designed to further investigate the therapeutic potential that stem cell therapy may hold for pediatric populations with single ventricle physiology. In this review, we discuss the stem cell types used in these populations, some preclinical studies, and the clinical trials of stem cell therapy in single ventricle patients.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalSeminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual
StatePublished - Jan 2021


  • Cavopulmonary shunt
  • Fontan circulation
  • Heart failure
  • Right ventricle
  • Single ventricle
  • Stem cells
  • Systemic ventricle

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Cardiology and Cardiovascular Medicine


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