Stem Cells and Spinal Fusion

Vivek P. Shah*, Wellington K. Hsu

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

There are a number of bone regeneration therapeutics available to aid spinal fusion; however, many are associated with pseudarthrosis, inflammation, and other complications. Mesenchymal stem cells for fusion has been promoted to mitigate these risks and achieve successful bony fusion. This article reviews the clinical studies available with use in spinal fusion. Preliminary results demonstrate that stem cells can provide high rates of fusion, comparable to autograft, without associated morbidity. Autologous and allogeneic stem cell sources showed similar rates of fusion in this review. Further research is required to evaluate which clinical situations are the optimum for stem cell use.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalNeurosurgery clinics of North America
Volume31
Issue number1
DOIs
StatePublished - Jan 2020

Fingerprint

Spinal Fusion
Cell Fusion
Stem Cells
Pseudarthrosis
Bone Regeneration
Autografts
Mesenchymal Stromal Cells
Inflammation
Morbidity
Research
Therapeutics

Keywords

  • Allogeneic
  • Autologous
  • Mesenchymal stem cells
  • Spine fusion
  • Stem cell

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Shah, Vivek P. ; Hsu, Wellington K. / Stem Cells and Spinal Fusion. In: Neurosurgery clinics of North America. 2020 ; Vol. 31, No. 1. pp. 65-72.
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Stem Cells and Spinal Fusion. / Shah, Vivek P.; Hsu, Wellington K.

In: Neurosurgery clinics of North America, Vol. 31, No. 1, 01.2020, p. 65-72.

Research output: Contribution to journalReview article

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