Stepwise Evolution of the Structure and Electronic Properties of DNA

Frederick D Lewis*, Xiaoyang Liu, Yansheng Wu, Xiaobing Zuo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


The optical properties of a family of duplex DNA conjugates possessing from 1 to 11 A:T base pairs and covalently attached stilbene chromophores at both ends have been investigated. As few as from two to four base bairs are needed to establish base-pair absorption and circular dichroism spectra similar to those of longer oligomers. The stilbene chromophores exhibit exciton-coupled circular dichroism, which can be observed even with 11 intervening base pairs, a distance of ca. 40 Å. The dependence of the sign and amplitude of these spectra reveals the ability of B-DNA to serve as a helical ruler.

Original languageEnglish (US)
Pages (from-to)12729-12731
Number of pages3
JournalJournal of the American Chemical Society
Issue number42
StatePublished - Oct 22 2003

ASJC Scopus subject areas

  • Chemistry(all)


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