Stepwise Evolution of the Structure and Electronic Properties of DNA

Frederick D Lewis; Xiaoyang Liu; Yansheng Wu; Xiaobing Zuo

doi:10.1021/ja036449k

Stepwise Evolution of the Structure and Electronic Properties of DNA

Frederick D Lewis^*, Xiaoyang Liu, Yansheng Wu, Xiaobing Zuo

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The optical properties of a family of duplex DNA conjugates possessing from 1 to 11 A:T base pairs and covalently attached stilbene chromophores at both ends have been investigated. As few as from two to four base bairs are needed to establish base-pair absorption and circular dichroism spectra similar to those of longer oligomers. The stilbene chromophores exhibit exciton-coupled circular dichroism, which can be observed even with 11 intervening base pairs, a distance of ca. 40 Å. The dependence of the sign and amplitude of these spectra reveals the ability of B-DNA to serve as a helical ruler.

Original language	English (US)
Pages (from-to)	12729-12731
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	125
Issue number	42
DOIs	https://doi.org/10.1021/ja036449k
State	Published - Oct 22 2003

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Chemistry(all)

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10.1021/ja036449k

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title = "Stepwise Evolution of the Structure and Electronic Properties of DNA",

abstract = "The optical properties of a family of duplex DNA conjugates possessing from 1 to 11 A:T base pairs and covalently attached stilbene chromophores at both ends have been investigated. As few as from two to four base bairs are needed to establish base-pair absorption and circular dichroism spectra similar to those of longer oligomers. The stilbene chromophores exhibit exciton-coupled circular dichroism, which can be observed even with 11 intervening base pairs, a distance of ca. 40 {\AA}. The dependence of the sign and amplitude of these spectra reveals the ability of B-DNA to serve as a helical ruler.",

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Y1 - 2003/10/22

N2 - The optical properties of a family of duplex DNA conjugates possessing from 1 to 11 A:T base pairs and covalently attached stilbene chromophores at both ends have been investigated. As few as from two to four base bairs are needed to establish base-pair absorption and circular dichroism spectra similar to those of longer oligomers. The stilbene chromophores exhibit exciton-coupled circular dichroism, which can be observed even with 11 intervening base pairs, a distance of ca. 40 Å. The dependence of the sign and amplitude of these spectra reveals the ability of B-DNA to serve as a helical ruler.

AB - The optical properties of a family of duplex DNA conjugates possessing from 1 to 11 A:T base pairs and covalently attached stilbene chromophores at both ends have been investigated. As few as from two to four base bairs are needed to establish base-pair absorption and circular dichroism spectra similar to those of longer oligomers. The stilbene chromophores exhibit exciton-coupled circular dichroism, which can be observed even with 11 intervening base pairs, a distance of ca. 40 Å. The dependence of the sign and amplitude of these spectra reveals the ability of B-DNA to serve as a helical ruler.

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Stepwise Evolution of the Structure and Electronic Properties of DNA

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