Abstract
The development of a stereoselective one-pot oxidative [3,3] sigmatropic rearrangement/Friedel-Crafts arylation that provides enantioenriched benzhydryl compounds is reported. The utility of this new transformation is demonstrated by the concise synthesis of several tetralone- and naphthyl-type lignan natural products, many of which display anti-malarial activity.
Original language | English (US) |
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Pages (from-to) | 1395-1398 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 53 |
Issue number | 5 |
DOIs | |
State | Published - Jan 27 2014 |
Keywords
- Cascade reactions
- Hydrazones
- Lignans
- Natural product synthesis
- Sigmatropic rearrangement
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)