Stereoselective hydrolysis of leucine oligomers

Neal E. Blair*, Frederick M. Dirbas, William A. Bonner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


A number of polymers derived from D-, L- and DL-leucine were subjected to partial hydrolysis under comparable conditions, with the finding that the polymers from DL-leucine were hydrolyzed more extensively than those from D- or L-leucine. Leucine polymers containing an excess of one enantiomer were partially hydrolyzed, resulting in an enhancement of the enantiomeric excess in the residual unhydrolyzed polymer and a depletion of the enantiomeric excess in the recovered monomer. These stereoselective hydrolyses are discussed from the viewpoint of the abiotic enhancement of optical activity on the primitive Earth.

Original languageEnglish (US)
Pages (from-to)27-29
Number of pages3
Issue number1
StatePublished - 1981

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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