Omuralide, a transformation product of the microbial metabolite lactacystin, was the first molecule discovered as a specific inhibitor of the proteasome and is unique in that it specifically inhibits the proteolytic activity of the 20S subunit of the proteasome without inhibiting any other protease activities of the cell. The total syntheses of omuralide and (+)-lactacystin are reported. An important key intermediate is synthesized at an early stage, which allows analogues of these two natural products to be made readily.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Organic Chemistry|
|State||Published - Oct 21 2011|
ASJC Scopus subject areas
- Organic Chemistry
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CCDC 856564: Experimental Crystal Structure Determination
Gu, W. (Creator) & Silverman, R. B. (Creator), Cambridge Crystallographic Data Centre, 2012
DOI: 10.5517/ccxrb32, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccxrb32&sid=DataCite