Steroid-dependent nephrotic syndrome following renal transplantation for congenital nephrotic syndrome

Pascale H. Lane*, H. William Schnaper, Robert L. Vernier, Timothy E. Bunchman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A boy developed recurrent steroid-responsive nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. The first episode was associated with mild tubulointerstitial rejection on kidney biopsy. Subsequent episodes showed normal histology by light microscopy and epithelial foot process fusion on electron microscopy, consistent with minimal change nephrotic syndrome. Serum analysis for soluble immune response suppressor was negative pre-nephrectomy, positive during each bout of nephrotic syndrome, and negative during each remission. This case represent de novo occurrence of steroid-sensitive minimal change nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. We stress the need for histological examination of the renal allograft to diagnose rejection, recurrent disease, or de novo disease.

Original languageEnglish (US)
Pages (from-to)300-303
Number of pages4
JournalPediatric Nephrology
Volume5
Issue number3
DOIs
StatePublished - May 1991

Keywords

  • Congenital nephrotic syndrome
  • Nephrotic syndrome
  • Renal transplant
  • Soluble immune response suppressor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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