Steroid metabolism in arrhenoblastoma

Jack E. Maidman; Robert T. Chatterton; W. S. Michael Arrata; Joseph Schifano; Judith A. Lueck

Steroid metabolism in arrhenoblastoma

Jack E. Maidman^*, Robert T. Chatterton, W. S. Michael Arrata, Joseph Schifano, Judith A. Lueck

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

An arrhenoblastoma that produced virilization in an 18-year-old girl was surgically removed and cultivated in vitro for over 60 days. Biochemical alterations caused by the tumor were studied in vivo and steroid metabolism was studied m vitro. Plasma testosterone dropped from 6.0 ng/ml to 0.7 ng/ml after the operation. Testosterone was produced by the tumor in tissue culture from tritiated pregnenolone. The Δ⁵ pathway by which the C, compounds are formed was found to be the major biosynthetic route in the tumor studied.

Original language	English (US)
Pages (from-to)	333-340
Number of pages	8
Journal	Obstetrics and gynecology
Volume	44
Issue number	3
State	Published - Sep 1974

ASJC Scopus subject areas

Obstetrics and Gynecology

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title = "Steroid metabolism in arrhenoblastoma",

abstract = "An arrhenoblastoma that produced virilization in an 18-year-old girl was surgically removed and cultivated in vitro for over 60 days. Biochemical alterations caused by the tumor were studied in vivo and steroid metabolism was studied m vitro. Plasma testosterone dropped from 6.0 ng/ml to 0.7 ng/ml after the operation. Testosterone was produced by the tumor in tissue culture from tritiated pregnenolone. The Δ5 pathway by which the C, compounds are formed was found to be the major biosynthetic route in the tumor studied.",

author = "Maidman, {Jack E.} and Chatterton, {Robert T.} and {Michael Arrata}, {W. S.} and Joseph Schifano and Lueck, {Judith A.}",

year = "1974",

month = sep,

language = "English (US)",

volume = "44",

pages = "333--340",

journal = "Obstetrics and Gynecology",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Steroid metabolism in arrhenoblastoma

AU - Maidman, Jack E.

AU - Chatterton, Robert T.

AU - Michael Arrata, W. S.

AU - Schifano, Joseph

AU - Lueck, Judith A.

PY - 1974/9

Y1 - 1974/9

N2 - An arrhenoblastoma that produced virilization in an 18-year-old girl was surgically removed and cultivated in vitro for over 60 days. Biochemical alterations caused by the tumor were studied in vivo and steroid metabolism was studied m vitro. Plasma testosterone dropped from 6.0 ng/ml to 0.7 ng/ml after the operation. Testosterone was produced by the tumor in tissue culture from tritiated pregnenolone. The Δ5 pathway by which the C, compounds are formed was found to be the major biosynthetic route in the tumor studied.

AB - An arrhenoblastoma that produced virilization in an 18-year-old girl was surgically removed and cultivated in vitro for over 60 days. Biochemical alterations caused by the tumor were studied in vivo and steroid metabolism was studied m vitro. Plasma testosterone dropped from 6.0 ng/ml to 0.7 ng/ml after the operation. Testosterone was produced by the tumor in tissue culture from tritiated pregnenolone. The Δ5 pathway by which the C, compounds are formed was found to be the major biosynthetic route in the tumor studied.

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M3 - Article

C2 - 4369211

AN - SCOPUS:0016302090

VL - 44

SP - 333

EP - 340

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 3

ER -

Steroid metabolism in arrhenoblastoma

Abstract

ASJC Scopus subject areas

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