Steroid metabolism in arrhenoblastoma

Jack E. Maidman*, Robert T. Chatterton, W. S. Michael Arrata, Joseph Schifano, Judith A. Lueck

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

An arrhenoblastoma that produced virilization in an 18-year-old girl was surgically removed and cultivated in vitro for over 60 days. Biochemical alterations caused by the tumor were studied in vivo and steroid metabolism was studied m vitro. Plasma testosterone dropped from 6.0 ng/ml to 0.7 ng/ml after the operation. Testosterone was produced by the tumor in tissue culture from tritiated pregnenolone. The Δ5 pathway by which the C, compounds are formed was found to be the major biosynthetic route in the tumor studied.

Original languageEnglish (US)
Pages (from-to)333-340
Number of pages8
JournalObstetrics and gynecology
Volume44
Issue number3
StatePublished - Sep 1974

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ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Maidman, J. E., Chatterton, R. T., Michael Arrata, W. S., Schifano, J., & Lueck, J. A. (1974). Steroid metabolism in arrhenoblastoma. Obstetrics and gynecology, 44(3), 333-340.