An arrhenoblastoma that produced virilization in an 18-year-old girl was surgically removed and cultivated in vitro for over 60 days. Biochemical alterations caused by the tumor were studied in vivo and steroid metabolism was studied m vitro. Plasma testosterone dropped from 6.0 ng/ml to 0.7 ng/ml after the operation. Testosterone was produced by the tumor in tissue culture from tritiated pregnenolone. The Δ5 pathway by which the C, compounds are formed was found to be the major biosynthetic route in the tumor studied.
|Original language||English (US)|
|Number of pages||8|
|Journal||Obstetrics and gynecology|
|State||Published - Sep 1974|
ASJC Scopus subject areas
- Obstetrics and Gynecology