Stimulated release of size-selected cargos in succession from mesoporous silica nanoparticles

Cheng Wang*, Zongxi Li, Dennis Cao, Yan Li Zhao, Justin W. Gaines, O. Altan Bozdemir, Michael W. Ambrogio, Marco Frasconi, Youssry Y. Botros, Jeffrey I. Zink, J. Fraser Stoddart

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

155 Scopus citations


Two birds with one stone: Covalent attachment of β-cyclodextrin rings (yellow; see figure) to mesoporous silica nanoparticles (MSNs) results in a dual-cargo release system into which differently sized cargos (blue and red spheres) can be loaded and then released in sequence when triggered by two different stimuli. The smaller molecules are released by lowering the pH value and the larger ones released after cleavage of the cyclodextrins from the MSN surface.

Original languageEnglish (US)
Pages (from-to)5460-5465
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number22
StatePublished - May 29 2012


  • cargo release
  • drug delivery
  • nanostructures
  • nanotechnology
  • β-cyclodextrins

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis


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