@article{f330fb448fa44b33b21afd91feaa981b,
title = "Stimulating the Hippocampal posteriormedial network enhances task-dependent connectivity and memory",
abstract = "Successful episodic memory involves dynamic increases in activity across distributed hippocampal networks, including the posterior-medial (PMN) and the anterior-temporal (ATN) networks. We tested whether this up-regulation of functional connectivity during memory processing can be enhanced within hippocampal networks by noninvasive stimulation, and whether such task-dependent connectivity enhancement predicts memory improvement. Participants received stimulation targeting the PMN or an out-of-network control location. We compared the effects of stimulation on fMRI connectivity during an autobiographical retrieval task versus during rest within the PMN and the ATN. PMN-targeted stimulation significantly increased connectivity during autobiographical retrieval versus rest within the PMN. This effect was not observed in the ATN, or in either network following control stimulation. Task-dependent increases in connectivity within the medial temporal lobe predicted improved performance of a separate episodic memory test. It is therefore possible to enhance the task-dependent regulation of hippocampal network connectivity that supports memory processing using noninvasive stimulation.",
author = "Warren, {Kristen N.} and Hermiller, {Molly S.} and Nilakantan, {Aneesha S.} and Voss, {Joel L.}",
note = "Funding Information: This project was funded by R01MH106512 from the National Institute of Mental Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors would like to thank Stephen VanHaerents for his assistance with TMS safety screening, Sungshin Kim for his contributions to the episodic memory task, and Jonathan O{\textquoteright}Neil, Robert Palumbo, Elise Gagnon, Melissa McSweeney, and Melissa Gunlogson for their roles in data collection. This research was supported in part through the computational resources and staff contributions provided for the Quest high-performance computing facility at Northwestern University, which is jointly supported by the Office of the Provost, the Office for Research, and Northwestern University Information Technology. Neuroimaging was performed at the Northwestern University Center for Translational Imaging, supported by Northwestern University Department of Radiology. Funding Information: R01MH106512 from the National Institute of Mental Health, National Institute of Mental Health R01MH106512, National Institute of Neurological Disorders and StrokeT32 NS047987 Publisher Copyright: {\textcopyright} 2019, eLife Sciences Publications Ltd. All rights reserved.",
year = "2019",
month = nov,
doi = "10.7554/eLife.49458",
language = "English (US)",
volume = "8",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}