Stimulation of colonic secretion by lipoxygenase metabolites of arachidonic acid

Mark W. Musch*, Richard J. Miller, Michael Field, Marvin I. Siegel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Both 5-hydroperoxyeicosatetraenoic acid (5-HPETE) and 5- hydroxyeicosatetraenoic acid (5-HETE) increased the short-circuit current (Isc) in rabbit colonic mucosa mounted in vitro in Ussing chambers. Measurements of chlorine-36 fluxes indicated that the Isc response to 5-HPETE is due to stimulation of active chlorine secretion. 9-, 11-, and 12-HPETE's and leukotrienes C4 and B4 produced either very small increases in Isc or no increase. In contrast to results in rabbit colon, no HPETE, HETE, or leukotriene was effective in rabbit ileal mucosa. The effects of 5-HPETE in the rabbit colon were unaffected by mepacrine, but could be partially blocked by indomethacin. These results suggest that drugs which block both cyclooxygenase and lipoxygenase may be effective antidiarrheals in patients with colitis.

Original languageEnglish (US)
Pages (from-to)1255-1256
Number of pages2
JournalScience
Volume217
Issue number4566
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • General

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