Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-β

John Varga, Sergio A. Jimenez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

Transforming growth factor-β (TGF β) a growth factor with diverse effects on cellular growth and metabolism, caused dramatic stimulation of total protein and collagen synthesis by confluent normal human dermal fibroblasts in culture in a dose-dependent manner. Gel electrophoresis of the newly synthesized macromolecules from the culture media of TGF β treated cultures demonstrated accelerated procollagen processing. These results indicate that TGF β is capable of qualitatively and quantitatively influencing the biosynthesis of matrix molecules by fibroblasts, and raise the possibility that TGF may play a role in the development of normal and pathologic fibrogenesis.

Original languageEnglish (US)
Pages (from-to)974-980
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume138
Issue number2
DOIs
StatePublished - Jul 31 1986

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-β'. Together they form a unique fingerprint.

Cite this