Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles

Dong-Hyun Kim, Elina A. Vitol, Jing Liu, Shankar Balasubramanian, David J. Gosztola, Ezra E. Cohen, Valentyn Novosad*, Elena A. Rozhkova

*Corresponding author for this work

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Hybrid nanoarchitectures are among the most promising nanotechnology- enabled materials for biomedical applications. Interfacing of nanoparticles with active materials gives rise to the structures with unique multiple functionality. Superparamagnetic iron oxide nanoparticles particles SPION are widely employed in the biology and in developing of advanced medical technologies. Polymeric micelles offer the advantage of multifunctional carriers which can serve as delivery vehicles carrying nanoparticles, hydrophobic chemotherapeutics and other functional materials and molecules. Stimuli-responsive polymers are especially attractive since their properties can be modulated in a controlled manner. Here we report on multifunctional thermo-responsive poly(N-isopropylacrylamide-co-acrylamide)-block-poly(ε- caprolactone) random block copolymer micelles as magnetic hyperthermia-mediated payload release and imaging agents. The combination of copolymers, nanoparticles and doxorubicin drug was tailored the way that the loaded micelles were cable to respond to magnetic heating at physiologically-relevant temperatures. A surface functionalization of the micelles with the integrin β4 antibody and consequent interfacing of the resulting nanobio hybrid with squamous head and neck carcinoma cells which is known to specifically over-express the A9 antigen resulted in concentration of the micelles on the surface of cells. No inherent cytotoxicity was detected for the magnetic micelles without external stimuli application. Furthermore, SPION-loaded micelles demonstrate significant MRI contrast enhancement abilities.

Original languageEnglish (US)
Pages (from-to)7425-7432
Number of pages8
JournalLangmuir
Volume29
Issue number24
DOIs
StatePublished - Jun 18 2013

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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    Kim, D-H., Vitol, E. A., Liu, J., Balasubramanian, S., Gosztola, D. J., Cohen, E. E., Novosad, V., & Rozhkova, E. A. (2013). Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles. Langmuir, 29(24), 7425-7432. https://doi.org/10.1021/la3044158