Abstract
DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyperinflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles. DNA nanoparticles regulated immunity via cytosolic DNA sensors that activate the signaling adaptor stimulator of interferon genes. In this review, we describe how DNA sensing to activate stimulator of interferon genes promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases, such as autoimmune syndromes or cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 155-165 |
| Number of pages | 11 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2014 |
Funding
H Lemos is supported by a postdoctoral fellowship from the Juvenile Diabetes Research Foundation, the Arthritis Foundation, and the Carlos and Marguerite Mason Trust and the NIH. AL Mellor is a consultant for NewLink Genetics Inc and receives income from this source, Research support from the NIH, the Arthritis Foundation and the Carlos and Marguerite Mason Trust. L Huang is supported by NIH grants and the Carlos and Marguerite Mason Trust. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Keywords
- DNA
- STING
- autoimmunity
- cancer
- immunity
- immunotherapy
- nanoparticles
- tolerance
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
