STING, nanoparticles, autoimmune disease and cancer: A novel paradigm for immunotherapy?

Henrique Lemos, Lei Huang, Tracy McGaha, Andrew L. Mellor*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyperinflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles. DNA nanoparticles regulated immunity via cytosolic DNA sensors that activate the signaling adaptor stimulator of interferon genes. In this review, we describe how DNA sensing to activate stimulator of interferon genes promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases, such as autoimmune syndromes or cancer.

Original languageEnglish (US)
Pages (from-to)155-165
Number of pages11
JournalExpert Review of Clinical Immunology
Issue number1
StatePublished - Jan 1 2014
Externally publishedYes


  • DNA
  • autoimmunity
  • cancer
  • immunity
  • immunotherapy
  • nanoparticles
  • tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'STING, nanoparticles, autoimmune disease and cancer: A novel paradigm for immunotherapy?'. Together they form a unique fingerprint.

Cite this