STING, nanoparticles, autoimmune disease and cancer: A novel paradigm for immunotherapy?

Henrique Lemos; Lei Huang; Tracy McGaha; Andrew L. Mellor

doi:10.1586/1744666X.2015.995097

STING, nanoparticles, autoimmune disease and cancer: A novel paradigm for immunotherapy?

Henrique Lemos, Lei Huang, Tracy McGaha, Andrew L. Mellor^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyperinflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles. DNA nanoparticles regulated immunity via cytosolic DNA sensors that activate the signaling adaptor stimulator of interferon genes. In this review, we describe how DNA sensing to activate stimulator of interferon genes promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases, such as autoimmune syndromes or cancer.

Original language	English (US)
Pages (from-to)	155-165
Number of pages	11
Journal	Expert Review of Clinical Immunology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1586/1744666X.2015.995097
State	Published - Jan 1 2014
Externally published	Yes

Keywords

DNA
STING
autoimmunity
cancer
immunity
immunotherapy
nanoparticles
tolerance

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1586/1744666X.2015.995097

Cite this

@article{fca8b60ac323444fb170865fffbdbcf1,

title = "STING, nanoparticles, autoimmune disease and cancer: A novel paradigm for immunotherapy?",

abstract = "DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyperinflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles. DNA nanoparticles regulated immunity via cytosolic DNA sensors that activate the signaling adaptor stimulator of interferon genes. In this review, we describe how DNA sensing to activate stimulator of interferon genes promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases, such as autoimmune syndromes or cancer.",

keywords = "DNA, STING, autoimmunity, cancer, immunity, immunotherapy, nanoparticles, tolerance",

author = "Henrique Lemos and Lei Huang and Tracy McGaha and Mellor, {Andrew L.}",

note = "Funding Information: H Lemos is supported by a postdoctoral fellowship from the Juvenile Diabetes Research Foundation, the Arthritis Foundation, and the Carlos and Marguerite Mason Trust and the NIH. AL Mellor is a consultant for NewLink Genetics Inc and receives income from this source, Research support from the NIH, the Arthritis Foundation and the Carlos and Marguerite Mason Trust. L Huang is supported by NIH grants and the Carlos and Marguerite Mason Trust. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: {\textcopyright} 2015 Informa UK, Ltd.",

year = "2014",

month = jan,

day = "1",

doi = "10.1586/1744666X.2015.995097",

language = "English (US)",

volume = "11",

pages = "155--165",

journal = "Expert Review of Clinical Immunology",

issn = "1744-666X",

publisher = "Expert Reviews Ltd.",

number = "1",

}

TY - JOUR

T1 - STING, nanoparticles, autoimmune disease and cancer

T2 - A novel paradigm for immunotherapy?

AU - Lemos, Henrique

AU - Huang, Lei

AU - McGaha, Tracy

AU - Mellor, Andrew L.

N1 - Funding Information: H Lemos is supported by a postdoctoral fellowship from the Juvenile Diabetes Research Foundation, the Arthritis Foundation, and the Carlos and Marguerite Mason Trust and the NIH. AL Mellor is a consultant for NewLink Genetics Inc and receives income from this source, Research support from the NIH, the Arthritis Foundation and the Carlos and Marguerite Mason Trust. L Huang is supported by NIH grants and the Carlos and Marguerite Mason Trust. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: © 2015 Informa UK, Ltd.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyperinflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles. DNA nanoparticles regulated immunity via cytosolic DNA sensors that activate the signaling adaptor stimulator of interferon genes. In this review, we describe how DNA sensing to activate stimulator of interferon genes promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases, such as autoimmune syndromes or cancer.

AB - DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyperinflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles. DNA nanoparticles regulated immunity via cytosolic DNA sensors that activate the signaling adaptor stimulator of interferon genes. In this review, we describe how DNA sensing to activate stimulator of interferon genes promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases, such as autoimmune syndromes or cancer.

KW - DNA

KW - STING

KW - autoimmunity

KW - cancer

KW - immunity

KW - immunotherapy

KW - nanoparticles

KW - tolerance

UR - http://www.scopus.com/inward/record.url?scp=84919829618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919829618&partnerID=8YFLogxK

U2 - 10.1586/1744666X.2015.995097

DO - 10.1586/1744666X.2015.995097

M3 - Review article

C2 - 25521938

AN - SCOPUS:84919829618

SN - 1744-666X

VL - 11

SP - 155

EP - 165

JO - Expert Review of Clinical Immunology

JF - Expert Review of Clinical Immunology

IS - 1

ER -

STING, nanoparticles, autoimmune disease and cancer: A novel paradigm for immunotherapy?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this