Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age

Thomas J. Sandora; David N. Williams; Kaitlyn Daugherty; Christine Geer; Christine Cuddemi; Larry K. Kociolek; Xinhua Chen; Hua Xu; Timothy J. Savage; Alice Banz; Kevin W. Garey; Anne J. Gonzales-Luna; Ciarán P. Kelly; Nira R. Pollock

doi:10.1093/jpids/piac059

Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age

Thomas J. Sandora^*, David N. Williams, Kaitlyn Daugherty, Christine Geer, Christine Cuddemi, Larry K. Kociolek, Xinhua Chen, Hua Xu, Timothy J. Savage, Alice Banz, Kevin W. Garey, Anne J. Gonzales-Luna, Ciarán P. Kelly, Nira R. Pollock

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

In a prospective cohort study, stools from children <3 years with and without diarrhea who were Clostridioides difficile nucleic acid amplification test-positive underwent ultrasensitive and quantitative toxin measurement. Among 37 cases and 46 controls, toxin concentration distributions overlapped substantially. Toxin concentration alone does not distinguish C. difficile infection from colonization in young children.

Original language	English (US)
Pages (from-to)	454-458
Number of pages	5
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	11
Issue number	10
DOIs	https://doi.org/10.1093/jpids/piac059
State	Published - Oct 1 2022

Keywords

Clostridioides difficile
pediatrics

ASJC Scopus subject areas

General Medicine

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10.1093/jpids/piac059

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Sandora, T. J., Williams, D. N., Daugherty, K., Geer, C., Cuddemi, C., Kociolek, L. K., Chen, X., Xu, H., Savage, T. J., Banz, A., Garey, K. W., Gonzales-Luna, A. J., Kelly, C. P., & Pollock, N. R. (2022). Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age. Journal of the Pediatric Infectious Diseases Society, 11(10), 454-458. https://doi.org/10.1093/jpids/piac059

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title = "Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age",

abstract = "In a prospective cohort study, stools from children <3 years with and without diarrhea who were Clostridioides difficile nucleic acid amplification test-positive underwent ultrasensitive and quantitative toxin measurement. Among 37 cases and 46 controls, toxin concentration distributions overlapped substantially. Toxin concentration alone does not distinguish C. difficile infection from colonization in young children.",

keywords = "Clostridioides difficile, pediatrics",

author = "Sandora, {Thomas J.} and Williams, {David N.} and Kaitlyn Daugherty and Christine Geer and Christine Cuddemi and Kociolek, {Larry K.} and Xinhua Chen and Hua Xu and Savage, {Timothy J.} and Alice Banz and Garey, {Kevin W.} and Gonzales-Luna, {Anne J.} and Kelly, {Ciar{\'a}n P.} and Pollock, {Nira R.}",

year = "2022",

month = oct,

day = "1",

doi = "10.1093/jpids/piac059",

language = "English (US)",

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Sandora, TJ, Williams, DN, Daugherty, K, Geer, C, Cuddemi, C, Kociolek, LK, Chen, X, Xu, H, Savage, TJ, Banz, A, Garey, KW, Gonzales-Luna, AJ, Kelly, CP & Pollock, NR 2022, 'Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age', Journal of the Pediatric Infectious Diseases Society, vol. 11, no. 10, pp. 454-458. https://doi.org/10.1093/jpids/piac059

Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age. / Sandora, Thomas J.; Williams, David N.; Daugherty, Kaitlyn et al.
In: Journal of the Pediatric Infectious Diseases Society, Vol. 11, No. 10, 01.10.2022, p. 454-458.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age

AU - Sandora, Thomas J.

AU - Williams, David N.

AU - Daugherty, Kaitlyn

AU - Geer, Christine

AU - Cuddemi, Christine

AU - Kociolek, Larry K.

AU - Chen, Xinhua

AU - Xu, Hua

AU - Savage, Timothy J.

AU - Banz, Alice

AU - Garey, Kevin W.

AU - Gonzales-Luna, Anne J.

AU - Kelly, Ciarán P.

AU - Pollock, Nira R.

PY - 2022/10/1

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N2 - In a prospective cohort study, stools from children <3 years with and without diarrhea who were Clostridioides difficile nucleic acid amplification test-positive underwent ultrasensitive and quantitative toxin measurement. Among 37 cases and 46 controls, toxin concentration distributions overlapped substantially. Toxin concentration alone does not distinguish C. difficile infection from colonization in young children.

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Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age

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Keywords

ASJC Scopus subject areas

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