Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age

Thomas J. Sandora*, David N. Williams, Kaitlyn Daugherty, Christine Geer, Christine Cuddemi, Larry K. Kociolek, Xinhua Chen, Hua Xu, Timothy J. Savage, Alice Banz, Kevin W. Garey, Anne J. Gonzales-Luna, Ciarán P. Kelly, Nira R. Pollock

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In a prospective cohort study, stools from children <3 years with and without diarrhea who were Clostridioides difficile nucleic acid amplification test-positive underwent ultrasensitive and quantitative toxin measurement. Among 37 cases and 46 controls, toxin concentration distributions overlapped substantially. Toxin concentration alone does not distinguish C. difficile infection from colonization in young children.

Original languageEnglish (US)
Pages (from-to)454-458
Number of pages5
JournalJournal of the Pediatric Infectious Diseases Society
Volume11
Issue number10
DOIs
StatePublished - Oct 1 2022

Keywords

  • Clostridioides difficile
  • pediatrics

ASJC Scopus subject areas

  • General Medicine

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