STORI Plots Enable Accurate Tracking of Individual Ion Signals

Jared O. Kafader, Steven C. Beu, Bryan P. Early, Rafael D. Melani, Kenneth R. Durbin, Vlad Zabrouskov, Alexander A. Makarov, Joshua T. Maze, Deven L. Shinholt, Ping F. Yip, Neil L. Kelleher, Philip D. Compton, Michael W. Senko*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Charge detection mass spectrometry (CDMS) of low-level signals is currently limited to the analysis of individual ions that generate a persistent signal during the entire observation period. Ions that disintegrate during the observation period produce reduced frequency domain signal amplitudes, which lead to an underestimation of the ion charge state, and thus the ion mass. The charge assignment can only be corrected through an accurate determination of the time of ion disintegration. The traditional mechanisms for temporal signal analysis have severe limitations for temporal resolution, spectral resolution, and signal-to-noise ratios. Selective Temporal Overview of Resonant Ions (STORI) plots provide a new framework to accurately analyze low-level time domain signals of individual ions. STORI plots allow for complete correction of intermittent signals, the differentiation of single and multiple ions at the same frequency, and the association of signals that spontaneously change frequency. [Figure not available: see fulltext.].

Original languageEnglish (US)
Pages (from-to)2200-2203
Number of pages4
JournalJournal of the American Society for Mass Spectrometry
Issue number11
StatePublished - Nov 1 2019


  • Charge detection mass spectrometry
  • FT-MS
  • Ion signal analysis
  • Orbitrap
  • Single ion mass spectrometry

ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy


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