Strain differences in the immune response of mice to homologous sperm‐specific lactate dehydrogenase (LDH‐C4)

John W. Kille*, Thomas E. Wheat, Graham Mitchell, Erwin Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The sperm‐specific isozyme of murine lactate dehydrogenase (LDH‐C4 was injected into female mice of various strains. Two regulatory phenotypes characterize the resultant immunity to LDH‐C4: one is manifested by high, intermediate or low levels of response, the other by the immediate or delayed maturation of peak titer. The response of several strains can be classified as high (SWR, SJL, BABL/c, C3H/He) and intermediate to low (A, CBA, DBA/2, DBA/1, C57BL/6) according to the level of antibody production and cell mediated immunity. BALB/c, SJL and SWR strains are immediate responders while and C3H/He mice are clearly delayed responders. Maturation and magnitude of response do not appear to be related. Both the antibody and cell mediated responses are T‐dependent, but are not obviously associated with Ig allotype or H‐2 regulation.

Original languageEnglish (US)
Pages (from-to)259-265
Number of pages7
JournalJournal of Experimental Zoology
Volume204
Issue number2
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Animal Science and Zoology

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