Strange as it may seem: The many links between Wnt signaling, planar cell polarity, and cilia

John B. Wallingford, Brian Mitchell

Research output: Contribution to journalReview articlepeer-review

235 Scopus citations

Abstract

Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the canonical Wnt/β-catenin pathway and the noncanonical Wnt/planar cell polarity (PCP) pathway. Furthermore, we address the evidence implicating a role for PCP components in ciliogenesis. Given the lack of consensus in the field, we use new data on the control of ciliary protein localization as a basis for proposing new models by which cell type-specific regulation of ciliary components via differential transport, regulated entry and exit, or diffusion barriers might generate context-dependent functions for cilia.

Original languageEnglish (US)
Pages (from-to)201-213
Number of pages13
JournalGenes and Development
Volume25
Issue number3
DOIs
StatePublished - Feb 1 2011

Keywords

  • Basal bodies
  • Cilia
  • Ciliary pores
  • Diffusion barriers
  • IFT
  • Planar cell polarity
  • Wnt signaling

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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