Strategies for optimizing the diagnostic predictive value of clostridium difficile molecular diagnostics

Larry K. Kociolek*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Because nucleic acid amplification tests (NAATs) do not distinguish Clostridium difficile infection (CDI) and asymptomatic C. difficile carriage, the diagnostic predictive value of NAATs is limited when used in patients with a low probability of CDI. In this issue of the Journal of Clinical Microbiology, Truong et al. (J. Clin. Microbiol., 55:1276 - 1284, 2017, https://doi.org/10.1128/JCM.02319-16) report significant reductions in hospital-onset CDI and oral vancomycin utilization at their institution following implementation of a novel intervention that leveraged their clinical bioinformatics resources to prevent C. difficile testing of stools from patients without clinically significant diarrhea and in patients with recent laxative use.

Original languageEnglish (US)
Pages (from-to)1244-1248
Number of pages5
JournalJournal of clinical microbiology
Volume55
Issue number5
DOIs
StatePublished - May 2017

ASJC Scopus subject areas

  • Microbiology (medical)

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