Strategies for the treatment of acute promyelocytic leukemia

Olga Frankfurt*, Martin S. Tallman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


The outcome of acute promyelocytic leukemia (APL) has improved dramatically during the past 40 years. Insights into the genetic and biologic mechanisms of APL lead to the development of specific and effective therapeutic strategies. This article discusses the therapeutic interventions that transformed APL from one of the most lethal leukemias to one that is highly curable.

Original languageEnglish (US)
Pages (from-to)37-50
Number of pages14
JournalJNCCN Journal of the National Comprehensive Cancer Network
Issue number1
StatePublished - Jan 2006


  • Acute promyelocytic leukemia
  • All-trans-retinoic acid
  • Arsenic trioxide
  • PML-RARα
  • Retinoic acid syndrome

ASJC Scopus subject areas

  • Oncology


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