Abstract
The outcome of acute promyelocytic leukemia (APL) has improved dramatically during the past 40 years. Insights into the genetic and biologic mechanisms of APL lead to the development of specific and effective therapeutic strategies. This article discusses the therapeutic interventions that transformed APL from one of the most lethal leukemias to one that is highly curable.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 37-50 |
| Number of pages | 14 |
| Journal | JNCCN Journal of the National Comprehensive Cancer Network |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2006 |
Keywords
- Acute promyelocytic leukemia
- All-trans-retinoic acid
- Arsenic trioxide
- PML-RARα
- Retinoic acid syndrome
ASJC Scopus subject areas
- Oncology