Strategies to Reduce the Risk of Contrast-Induced Nephropathy

Fulvio Stacul*, Andy Adam, Christoph R. Becker, Charles Davidson, Norbert Lameire, Peter A. McCullough, James Tumlin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

215 Scopus citations


In view of the clinical importance of contrast-induced nephropathy (CIN), numerous potential risk-reduction strategies have been evaluated. Adequate intravenous volume expansion with isotonic crystalloid (1.0-1.5 mL/kg per hr) for 3-12 hours before the procedure and continued for 6-24 hours afterward can lessen the probability of CIN in patients at risk. There are insufficient data on oral fluids (as opposed to intravenous volume expansion) as a CIN-prevention strategy. No adjunctive medical or mechanical treatment has been proved to be efficacious in reducing risk for CIN. Prophylactic hemodialysis and hemofiltration have not been validated as effective strategies. The CIN Consensus Working Panel considered that, of the pharmacologic agents that have been evaluated, theophylline, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins), ascorbic acid, and prostaglandin E1 deserve further evaluation. N-acetylcysteine is not consistently effective in reducing the risk for CIN. Fenoldopam, dopamine, calcium channel blockers, atrial natriuretic peptide, and l-arginine have not been shown to be effective. Use of furosemide, mannitol, or an endothelin receptor antagonist is potentially detrimental. Nephrotoxic drugs should be withdrawn before contrast administration in patients at risk for CIN.

Original languageEnglish (US)
Pages (from-to)59-77
Number of pages19
JournalAmerican Journal of Cardiology
Issue number6 SUPPL. 1
StatePublished - Sep 18 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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