Abstract
Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence is often hampered by inadequate reporting. Reporting guidelines help authors effectively communicate all critical information about what was done and what was found. STROBE-MR (strengthening the reporting of observational studies in epidemiology using mendelian randomisation) assists authors in reporting their MR research clearly and transparently. Adopting STROBE-MR should help readers, reviewers, and journal editors evaluate the quality of published MR studies. This article explains the 20 items of the STROBE-MR checklist, along with their meaning and rationale, using terms defined in a glossary. Examples of transparent reporting are used for each item to illustrate best practices.
| Original language | English (US) |
|---|---|
| Article number | n2233 |
| Journal | The BMJ |
| Volume | 375 |
| DOIs | |
| State | Published - Oct 26 2021 |
Funding
Funding: All STROBE-MR Initiative members are volunteers. Support for this initiative was provided by the International Swiss National Science Foundation (SNSF), UK National Institute for Health Research (NIHR) Biomedical Research Centre at University Hospitals Bristol, Weston NHS Foundation Trust, and the University of Bristol. The UK Medical Research Council (MRC) and University of Bristol support the MRC Integrative Epidemiology Unit (MC_UU_00011/1). RCR is a de Pass Vice Chancellor’s Research Fellow at the University of Bristol. NMD is supported by a Norwegian Research Council (grant 295989). SAS was supported by an NWO/ZonMW Veni grant (91617066). NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the principal investigator of the Avon Longitudinal Study of Parents and Children (MRC and WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215-2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the Cancer Research UK Integrative Cancer Epidemiology Programme (C18281/A19169). JPTH is supported by NIHR Bristol Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol; is a member of the MRC Integrative Epidemiology Unit at the University of Bristol; and is an NIHR senior investigator (NF-SI-0617-10145). ME is supported by the Swiss National Science Foundation (grant 189498). JBR is supported by the Canadian Institutes of Health Research (365825; 409511), Lady Davis Institute of the Jewish General Hospital, Canadian Foundation for Innovation, NIH Foundation, CRUK, Genome Québec, Public Health Agency of Canada, and Fonds de Recherche Québec Santé. TJV was funded by US National Institutes of Health grant R01 CA222147. BARW is funded by the Economic and Social Research Council South West Doctoral Training Partnership 1+3 PhD Studentship Award (ES/P000630/1). Support from Calcul Québec and Compute Canada is acknowledged. TwinsUK is funded by the Welcome Trust, MRC, European Union, the NIHR funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. These funding agencies had no role in the design, implementation or interpretation of this study. The views expressed are those of the authors and not necessarily those of the SNSF, NIHR, Weston NHS Foundation Trust, or University of Bristol, NHS, MRC, or Department of Health and Social Care. Funders had no role in the design, conduct or results interpretation in this project. “Competing interests: All authors have completed the International Committee of Medical Journal Editors (ICMJE) uniform disclosure form at www.icmje.org/ coi_disclosure.pdf. ARC, DG, TT, JV, REW, GH, RM, SS, SB, GDS, MVH, IT, and AD declare no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work. MRM reports grants from Pfizer and non-financial support from GlaxoSmithKline, outside the submitted work. NMD reports grants from ESRC, grants from MRC, during the conduct of the study; grants from GRAND/ Pfizer for unrelated research, outside the submitted work. AET reports grants from Pfizer, outside the submitted work. LDH reports grants from MRC, during the conduct of the study. DW reports grants from NIH, during the conduct of the study.”89 “Funding: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the Ministère de l’Économie, de la Science et de l’Innovation du Québec through Genome Québec and grant PSR-SIIRI-701, the National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/ A16563, C1287/A10710), and the European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al.25 RCR, ELA, BMB, CLR, RMM, MM, DAL, and GDS are members of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the Medical Research Council (grant Nos MM_UU_00011/1, MC_ UU_00011/2, MC_UU_00011/5, MC_UU_00011/6, and MC_UU_00011/7). RCR is a de Pass VC research fellow at the University of Bristol. This study was supported by the NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service, National Institute for Health Research, or Department of Health and Social Care. This work was also supported by Cancer Research UK (grant No C18281/A19169) and the Economic and Social Research Council (grant No ES/N000498/1). SEJ is funded by the Medical Research Council (grant No MR/M005070/1). TMF is supported by the European Research Council (grant No 323195:GLUCOSEGENES-FP7-IDEAS-ERC). MNW is supported by the Wellcome Trust Institutional Strategic Support Award (grant No WT097835MF).”120
ASJC Scopus subject areas
- General Medicine