Stress and asthma: Novel insights on genetic, epigenetic, and immunologic mechanisms

Stacy L. Rosenberg, Gregory E. Miller, John M. Brehm, Juan C. Celedón*

*Corresponding author for this work

Research output: Contribution to journalReview article

72 Scopus citations

Abstract

In the United States the economically disadvantaged and some ethnic minorities are often exposed to chronic psychosocial stressors and disproportionately affected by asthma. Current evidence suggests a causal association between chronic psychosocial stress and asthma or asthma morbidity. Recent findings suggest potential mechanisms underlying this association, including changes in the methylation and expression of genes that regulate behavioral, autonomic, neuroendocrine, and immunologic responses to stress. There is also evidence suggesting the existence of susceptibility genes that predispose chronically stressed youth to both post-traumatic stress disorder and asthma. In this review we critically examine published evidence and suggest future directions for research in this field.

Original languageEnglish (US)
Pages (from-to)1009-1015
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume134
Issue number5
DOIs
StatePublished - Nov 1 2014

Keywords

  • Asthma
  • genetics
  • immune system
  • neuroendocrine system
  • psychosocial stress

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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