Stress and the cell nucleus: Dynamics of gene expression and structural reorganization

Caroline Jolly, Richard I. Morimoto*

*Corresponding author for this work

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

A growing number of experimental observations reveal that the cell nucleus is functionally compartmentalized yet organized to ensure a dynamic response to events that influence nuclear activities. The cellular and molecular response to physiological and environmental stress induces a rapid and transient change in gene expression associated with major changes in nuclear architecture that impacts on signals involved in cell growth. In this review, we will address the effects of stress on the functional compartmentation of the cell nucleus and the dynamic reorganization of nuclear structures and function.

Original languageEnglish (US)
Pages (from-to)261-270
Number of pages10
JournalGene expression
Volume7
Issue number4-6
StatePublished - 1999

Keywords

  • HSFs
  • HSPs
  • Heat shock
  • Nuclear function
  • Nuclear structure

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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