Stress biology: Complexity and multifariousness in health and disease

Matthias P. Mayer; Laura Blair; Gregory L. Blatch; Thiago J. Borges; Ahmed Chadli; Gabriela Chiosis; Aurélie de Thonel; Albena Dinkova-Kostova; Heath Ecroyd; Adrienne L. Edkins; Takanori Eguchi; Monika Fleshner; Kevin P. Foley; Sotirios Fragkostefanakis; Jason Gestwicki; Pierre Goloubinoff; Jennifer A. Heritz; Christine M. Heske; Jonathan D. Hibshman; Jenny Joutsen; Wei Li; Michael Lynes; Marc L. Mendillo; Nahid Mivechi; Fortunate Mokoena; Yuka Okusha; Veena Prahlad; Elizabeth Repasky; Sara Sannino; Federica Scalia; Reut Shalgi; Lea Sistonen; Emily Sontag; Patricija van Oosten-Hawle; Anniina Vihervaara; Anushka Wickramaratne; Shawn Xiang Yang Wang; Tawanda Zininga

doi:10.1016/j.cstres.2024.01.006

Stress biology: Complexity and multifariousness in health and disease

Matthias P. Mayer^*, Laura Blair, Gregory L. Blatch, Thiago J. Borges, Ahmed Chadli, Gabriela Chiosis, Aurélie de Thonel, Albena Dinkova-Kostova, Heath Ecroyd, Adrienne L. Edkins, Takanori Eguchi, Monika Fleshner, Kevin P. Foley, Sotirios Fragkostefanakis, Jason Gestwicki, Pierre Goloubinoff, Jennifer A. Heritz, Christine M. Heske, Jonathan D. Hibshman, Jenny JoutsenWei Li, Michael Lynes, Marc L. Mendillo, Nahid Mivechi, Fortunate Mokoena, Yuka Okusha, Veena Prahlad, Elizabeth Repasky, Sara Sannino, Federica Scalia, Reut Shalgi, Lea Sistonen, Emily Sontag, Patricija van Oosten-Hawle, Anniina Vihervaara, Anushka Wickramaratne, Shawn Xiang Yang Wang, Tawanda Zininga

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.

Original language	English (US)
Pages (from-to)	143-157
Number of pages	15
Journal	Cell Stress and Chaperones
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.cstres.2024.01.006
State	Published - Feb 2024

Funding

The authors thank Stuart Calderwood (Harvard Medical School), Leonard Neckers (National Cancer Institute), and Elizabeth Repasky (Roswell Park Comprehensive Cancer Center) for organizing the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment. The authors acknowledge the Department of Urology at SUNY Upstate Medical University and the Cell Stress Society International, Inc for their generous support. The authors also express their gratitude to Eppendorf, Nicoya Lifesciences, Sino Biological, and StressMarq Biosciences for their meeting sponsorship.

Keywords

Heat shock proteins
Heat shock response
Heat shock transcription factors
Molecular chaperones
Protein folding diseases
Stress response

ASJC Scopus subject areas

Biochemistry
Cell Biology

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10.1016/j.cstres.2024.01.006

Cite this

Mayer, M. P., Blair, L., Blatch, G. L., Borges, T. J., Chadli, A., Chiosis, G., de Thonel, A., Dinkova-Kostova, A., Ecroyd, H., Edkins, A. L., Eguchi, T., Fleshner, M., Foley, K. P., Fragkostefanakis, S., Gestwicki, J., Goloubinoff, P., Heritz, J. A., Heske, C. M., Hibshman, J. D., ... Zininga, T. (2024). Stress biology: Complexity and multifariousness in health and disease. Cell Stress and Chaperones, 29(1), 143-157. https://doi.org/10.1016/j.cstres.2024.01.006

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abstract = "Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.",

keywords = "Heat shock proteins, Heat shock response, Heat shock transcription factors, Molecular chaperones, Protein folding diseases, Stress response",

author = "Mayer, {Matthias P.} and Laura Blair and Blatch, {Gregory L.} and Borges, {Thiago J.} and Ahmed Chadli and Gabriela Chiosis and {de Thonel}, Aur{\'e}lie and Albena Dinkova-Kostova and Heath Ecroyd and Edkins, {Adrienne L.} and Takanori Eguchi and Monika Fleshner and Foley, {Kevin P.} and Sotirios Fragkostefanakis and Jason Gestwicki and Pierre Goloubinoff and Heritz, {Jennifer A.} and Heske, {Christine M.} and Hibshman, {Jonathan D.} and Jenny Joutsen and Wei Li and Michael Lynes and Mendillo, {Marc L.} and Nahid Mivechi and Fortunate Mokoena and Yuka Okusha and Veena Prahlad and Elizabeth Repasky and Sara Sannino and Federica Scalia and Reut Shalgi and Lea Sistonen and Emily Sontag and {van Oosten-Hawle}, Patricija and Anniina Vihervaara and Anushka Wickramaratne and Wang, {Shawn Xiang Yang} and Tawanda Zininga",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = feb,

doi = "10.1016/j.cstres.2024.01.006",

language = "English (US)",

volume = "29",

pages = "143--157",

journal = "Cell Stress and Chaperones",

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Mayer, MP, Blair, L, Blatch, GL, Borges, TJ, Chadli, A, Chiosis, G, de Thonel, A, Dinkova-Kostova, A, Ecroyd, H, Edkins, AL, Eguchi, T, Fleshner, M, Foley, KP, Fragkostefanakis, S, Gestwicki, J, Goloubinoff, P, Heritz, JA, Heske, CM, Hibshman, JD, Joutsen, J, Li, W, Lynes, M, Mendillo, ML, Mivechi, N, Mokoena, F, Okusha, Y, Prahlad, V, Repasky, E, Sannino, S, Scalia, F, Shalgi, R, Sistonen, L, Sontag, E, van Oosten-Hawle, P, Vihervaara, A, Wickramaratne, A, Wang, SXY & Zininga, T 2024, 'Stress biology: Complexity and multifariousness in health and disease', Cell Stress and Chaperones, vol. 29, no. 1, pp. 143-157. https://doi.org/10.1016/j.cstres.2024.01.006

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T2 - Complexity and multifariousness in health and disease

AU - Mayer, Matthias P.

AU - Blair, Laura

AU - Blatch, Gregory L.

AU - Borges, Thiago J.

AU - Chadli, Ahmed

AU - Chiosis, Gabriela

AU - de Thonel, Aurélie

AU - Dinkova-Kostova, Albena

AU - Ecroyd, Heath

AU - Edkins, Adrienne L.

AU - Eguchi, Takanori

AU - Fleshner, Monika

AU - Foley, Kevin P.

AU - Fragkostefanakis, Sotirios

AU - Gestwicki, Jason

AU - Goloubinoff, Pierre

AU - Heritz, Jennifer A.

AU - Heske, Christine M.

AU - Hibshman, Jonathan D.

AU - Joutsen, Jenny

AU - Li, Wei

AU - Lynes, Michael

AU - Mendillo, Marc L.

AU - Mivechi, Nahid

AU - Mokoena, Fortunate

AU - Okusha, Yuka

AU - Prahlad, Veena

AU - Repasky, Elizabeth

AU - Sannino, Sara

AU - Scalia, Federica

AU - Shalgi, Reut

AU - Sistonen, Lea

AU - Sontag, Emily

AU - van Oosten-Hawle, Patricija

AU - Vihervaara, Anniina

AU - Wickramaratne, Anushka

AU - Wang, Shawn Xiang Yang

AU - Zininga, Tawanda

PY - 2024/2

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N2 - Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.

AB - Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.

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KW - Protein folding diseases

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Stress biology: Complexity and multifariousness in health and disease

Abstract

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Keywords

ASJC Scopus subject areas

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