TY - JOUR
T1 - Stress biology
T2 - Complexity and multifariousness in health and disease
AU - Mayer, Matthias P.
AU - Blair, Laura
AU - Blatch, Gregory L.
AU - Borges, Thiago J.
AU - Chadli, Ahmed
AU - Chiosis, Gabriela
AU - de Thonel, Aurélie
AU - Dinkova-Kostova, Albena
AU - Ecroyd, Heath
AU - Edkins, Adrienne L.
AU - Eguchi, Takanori
AU - Fleshner, Monika
AU - Foley, Kevin P.
AU - Fragkostefanakis, Sotirios
AU - Gestwicki, Jason
AU - Goloubinoff, Pierre
AU - Heritz, Jennifer A.
AU - Heske, Christine M.
AU - Hibshman, Jonathan D.
AU - Joutsen, Jenny
AU - Li, Wei
AU - Lynes, Michael
AU - Mendillo, Marc L.
AU - Mivechi, Nahid
AU - Mokoena, Fortunate
AU - Okusha, Yuka
AU - Prahlad, Veena
AU - Repasky, Elizabeth
AU - Sannino, Sara
AU - Scalia, Federica
AU - Shalgi, Reut
AU - Sistonen, Lea
AU - Sontag, Emily
AU - van Oosten-Hawle, Patricija
AU - Vihervaara, Anniina
AU - Wickramaratne, Anushka
AU - Wang, Shawn Xiang Yang
AU - Zininga, Tawanda
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/2
Y1 - 2024/2
N2 - Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.
AB - Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.
KW - Heat shock proteins
KW - Heat shock response
KW - Heat shock transcription factors
KW - Molecular chaperones
KW - Protein folding diseases
KW - Stress response
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U2 - 10.1016/j.cstres.2024.01.006
DO - 10.1016/j.cstres.2024.01.006
M3 - Article
C2 - 38311120
AN - SCOPUS:85185460130
SN - 1355-8145
VL - 29
SP - 143
EP - 157
JO - Cell Stress and Chaperones
JF - Cell Stress and Chaperones
IS - 1
ER -