Stress-dependent enhancement and impairment of retention by naloxone: Evidence for an endogenous opioid-based modulatory system protective of memory

Allen M. Schneider*, Peter E. Simson, Krista Spiller, Jonathan Adelstein, Amanda Vacharat, Kenneth R. Short, Lynn G. Kirby

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The opiate-receptor antagonist naloxone was administered to rats after passive-avoidance training either alone or in combination with forced-swim stress. A retention test revealed that while naloxone enhanced retention when administered alone, it impaired retention when administered in combination with forced-swim stress. The findings provide evidence for a "protective" endogenous opioid-based system that, when not blocked pharmacologically, limits enhancement or impairment of retention under conditions of mild and intense stress, respectively.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalBehavioural Brain Research
Volume205
Issue number1
DOIs
StatePublished - Dec 14 2009

Keywords

  • Adrenergic
  • Forced-swim
  • Memory modulation
  • Naloxone
  • Opioid
  • Stress

ASJC Scopus subject areas

  • Behavioral Neuroscience

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