Stress-dependent enhancement and impairment of retention by naloxone: Evidence for an endogenous opioid-based modulatory system protective of memory

Allen M. Schneider; Peter E. Simson; Krista Spiller; Jonathan Adelstein; Amanda Vacharat; Kenneth R. Short; Lynn G. Kirby

doi:10.1016/j.bbr.2009.06.007

Stress-dependent enhancement and impairment of retention by naloxone: Evidence for an endogenous opioid-based modulatory system protective of memory

Allen M. Schneider^*, Peter E. Simson, Krista Spiller, Jonathan Adelstein, Amanda Vacharat, Kenneth R. Short, Lynn G. Kirby

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The opiate-receptor antagonist naloxone was administered to rats after passive-avoidance training either alone or in combination with forced-swim stress. A retention test revealed that while naloxone enhanced retention when administered alone, it impaired retention when administered in combination with forced-swim stress. The findings provide evidence for a "protective" endogenous opioid-based system that, when not blocked pharmacologically, limits enhancement or impairment of retention under conditions of mild and intense stress, respectively.

Original language	English (US)
Pages (from-to)	290-293
Number of pages	4
Journal	Behavioural Brain Research
Volume	205
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2009.06.007
State	Published - Dec 14 2009

Keywords

Adrenergic
Forced-swim
Memory modulation
Naloxone
Opioid
Stress

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2009.06.007

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abstract = "The opiate-receptor antagonist naloxone was administered to rats after passive-avoidance training either alone or in combination with forced-swim stress. A retention test revealed that while naloxone enhanced retention when administered alone, it impaired retention when administered in combination with forced-swim stress. The findings provide evidence for a {"}protective{"} endogenous opioid-based system that, when not blocked pharmacologically, limits enhancement or impairment of retention under conditions of mild and intense stress, respectively.",

keywords = "Adrenergic, Forced-swim, Memory modulation, Naloxone, Opioid, Stress",

author = "Schneider, {Allen M.} and Simson, {Peter E.} and Krista Spiller and Jonathan Adelstein and Amanda Vacharat and Short, {Kenneth R.} and Kirby, {Lynn G.}",

note = "Funding Information: This work was supported by a grant from the Howard Hughes Medical Institute to Swarthmore College and a grant from the National Institute on Drug Abuse (DA 20126) to L. Kirby. Ranga Atapattu, Luis Hernandez and Adam Miller expertly assisted in conducting the experiments. Dr. E. Carr Everbach, Department of Engineering, Swarthmore College, expertly assisted in programming the behavioral equipment.",

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AU - Adelstein, Jonathan

AU - Vacharat, Amanda

AU - Short, Kenneth R.

AU - Kirby, Lynn G.

N1 - Funding Information: This work was supported by a grant from the Howard Hughes Medical Institute to Swarthmore College and a grant from the National Institute on Drug Abuse (DA 20126) to L. Kirby. Ranga Atapattu, Luis Hernandez and Adam Miller expertly assisted in conducting the experiments. Dr. E. Carr Everbach, Department of Engineering, Swarthmore College, expertly assisted in programming the behavioral equipment.

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N2 - The opiate-receptor antagonist naloxone was administered to rats after passive-avoidance training either alone or in combination with forced-swim stress. A retention test revealed that while naloxone enhanced retention when administered alone, it impaired retention when administered in combination with forced-swim stress. The findings provide evidence for a "protective" endogenous opioid-based system that, when not blocked pharmacologically, limits enhancement or impairment of retention under conditions of mild and intense stress, respectively.

AB - The opiate-receptor antagonist naloxone was administered to rats after passive-avoidance training either alone or in combination with forced-swim stress. A retention test revealed that while naloxone enhanced retention when administered alone, it impaired retention when administered in combination with forced-swim stress. The findings provide evidence for a "protective" endogenous opioid-based system that, when not blocked pharmacologically, limits enhancement or impairment of retention under conditions of mild and intense stress, respectively.

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KW - Naloxone

KW - Opioid

KW - Stress

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Stress-dependent enhancement and impairment of retention by naloxone: Evidence for an endogenous opioid-based modulatory system protective of memory

Abstract

Keywords

ASJC Scopus subject areas

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