Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection

Richard I. Morimoto*, M. Gabriella Santoro

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

483 Scopus citations

Abstract

Molecular chaperones protect proteins against environmental and physiologic stress and from the deleterious consequences of an imbalance in protein homeostasis. Many of these stresses, if prolonged, result in defective development and pathologies associated with a diverse array of diseases due to tissue injury and repair including stroke, myocardial reperfusion damage, ischemia, cancer, amyloidosis, and other neurodegenerative diseases. We discuss the molecular nature of the stress signals, the mechanisms that underlie activation of the heat shock response, the role of heat shock proteins as cytoprotective molecules, and strategies for pharmacologically active molecules as regulators of the heat shock response.

Original languageEnglish (US)
Pages (from-to)833-838
Number of pages6
JournalNature biotechnology
Volume16
Issue number9
DOIs
StatePublished - Jan 1 1998

Keywords

  • Drug design
  • Stress response
  • Therapeutics

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering

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