Stress regulation in multiple sclerosis - Current issues and concepts

Christoph Heesen*, D. C. Mohr, I. Huitinga, F. Then Bergh, J. Gaab, C. Otte, S. M. Gold

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Since its first description by Charcot, psychological stress has been considered a triggering factor for exacerbations in multiple sclerosis, but until recently the clinical evidence for a causal relation was weak. Over the past years, a growing number of studies have started to elucidate this association and highlight potential mechanisms, including brain-immune communication. On 5 June 2005, a panel of international researchers discussed the current evidence. This article summarizes the observational, animal experimental, as well as human experimental findings on stress regulation in MS, as well as studies on the functioning of the major stress response systems, ie, the hypothalamo-pituitary-adrenal (HPA) axis and the autonomous nervous system (ANS) in MS. Consensus statements from the group to these aspects are given. Research objectives and strategies are delineated, as well as clinical implications.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalMultiple Sclerosis
Issue number2
StatePublished - Mar 1 2007


  • Adrenoreceptor
  • Autonomous nervous system
  • Experimental stress
  • Glucocorticoids
  • Hypothalamo-pituitary-adrenal axis
  • Stressful life events

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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