Striatal cholinergic interneurons and Parkinson's disease

Asami Tanimura, Tristano Pancani, Sean Austin O. Lim, Cecilia Tubert, Alexandra E. Melendez, Weixing Shen, Dalton James Surmeier*

*Corresponding author for this work

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Giant, aspiny cholinergic interneurons (ChIs) have long been known to be key nodes in the striatal circuitry controlling goal-directed actions and habits. In recent years, new experimental approaches, like optogenetics and monosynaptic rabies virus mapping, have expanded our understanding of how ChIs contribute to the striatal activity underlying action selection and the interplay of dopaminergic and cholinergic signaling. These approaches also have begun to reveal how ChI function is distorted in disease states affecting the basal ganglia, like Parkinson's disease (PD). This review gives a brief overview of our current understanding of the functional role played by ChIs in striatal physiology and how this changes in PD. The translational implications of these discoveries, as well as the gaps that remain to be bridged, are discussed as well.

Original languageEnglish (US)
Pages (from-to)1148-1158
Number of pages11
JournalEuropean Journal of Neuroscience
Volume47
Issue number10
DOIs
StatePublished - May 2018

    Fingerprint

Keywords

  • G-protein-coupled receptor
  • dopamine
  • dyskinesia
  • electrophysiology
  • neuromodulation
  • striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this