Striatal synapses, circuits, and Parkinson's disease

Shenyu Zhai, Asami Tanimura, Steven Michael Graves, Weixing Shen, D. James Surmeier

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations


The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in the hypokinetic features of the disease. New tools to study brain circuitry have led to significant advances in our understanding of striatal circuits and how they adapt in PD models. This short review summarizes some of these recent studies and the gaps that remain to be filled.

Original languageEnglish (US)
Pages (from-to)9-16
Number of pages8
JournalCurrent opinion in neurobiology
StatePublished - Feb 2018

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Striatal synapses, circuits, and Parkinson's disease'. Together they form a unique fingerprint.

Cite this