Striatal volumes and dyskinetic movements in youth at high-risk for psychosis

Vijay A. Mittal; Melita Daley; Marisa F. Shiode; Carrie E. Bearden; Joseph O'Neill; Tyrone D. Cannon

doi:10.1016/j.schres.2010.08.002

Striatal volumes and dyskinetic movements in youth at high-risk for psychosis

Vijay A. Mittal^*, Melita Daley, Marisa F. Shiode, Carrie E. Bearden, Joseph O'Neill, Tyrone D. Cannon

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Although dyskinesias may be one of the first behavioral indicators of progressive striatal dysfunction, a mechanism critically implicated in the pathogenesis of psychotic disorders, little is known about the association between striatal structures and abnormal movements in high-risk populations. Thirty participants with a prodromal syndrome were rated for dyskinetic movements and underwent structural magnetic resonance imaging (MRI). Volumes of striatal brain structures were delineated. Elevated hyperkinetic movements were found to be associated with smaller putamen and results were replicated in the antipsychotic naïve portion of the sample. Participants who converted over a 2-year follow-up period showed significantly smaller striatal volumes and a trend towards elevated dyskinetic movements, relative to those who did not convert. Movement abnormalities may reflect a striatal pathology that is present before formal psychosis onset, and potentially reflective of a heightened vulnerability for conversion.

Original language	English (US)
Pages (from-to)	68-70
Number of pages	3
Journal	Schizophrenia Research
Volume	123
Issue number	1
DOIs	https://doi.org/10.1016/j.schres.2010.08.002
State	Published - Oct 2010

Funding

This research was supported by National Institutes of Health grant MH65079 to TDC, grants MH14584-33 and MH087258-01 to VM and a NARSAD 2010 Young Investigator grant to MD. Support was also provided by NIMH P50 MH066286 awarded to KN. NIMH and NARSAD had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

Keywords

Caudate
Conversion
Dyskinesia
Prodromal
Psychosis
Putamen

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2010.08.002

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title = "Striatal volumes and dyskinetic movements in youth at high-risk for psychosis",

abstract = "Although dyskinesias may be one of the first behavioral indicators of progressive striatal dysfunction, a mechanism critically implicated in the pathogenesis of psychotic disorders, little is known about the association between striatal structures and abnormal movements in high-risk populations. Thirty participants with a prodromal syndrome were rated for dyskinetic movements and underwent structural magnetic resonance imaging (MRI). Volumes of striatal brain structures were delineated. Elevated hyperkinetic movements were found to be associated with smaller putamen and results were replicated in the antipsychotic na{\"i}ve portion of the sample. Participants who converted over a 2-year follow-up period showed significantly smaller striatal volumes and a trend towards elevated dyskinetic movements, relative to those who did not convert. Movement abnormalities may reflect a striatal pathology that is present before formal psychosis onset, and potentially reflective of a heightened vulnerability for conversion.",

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note = "Funding Information: This research was supported by National Institutes of Health grant MH65079 to TDC, grants MH14584-33 and MH087258-01 to VM and a NARSAD 2010 Young Investigator grant to MD. Support was also provided by NIMH P50 MH066286 awarded to KN. NIMH and NARSAD had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. ",

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AU - O'Neill, Joseph

AU - Cannon, Tyrone D.

N1 - Funding Information: This research was supported by National Institutes of Health grant MH65079 to TDC, grants MH14584-33 and MH087258-01 to VM and a NARSAD 2010 Young Investigator grant to MD. Support was also provided by NIMH P50 MH066286 awarded to KN. NIMH and NARSAD had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

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N2 - Although dyskinesias may be one of the first behavioral indicators of progressive striatal dysfunction, a mechanism critically implicated in the pathogenesis of psychotic disorders, little is known about the association between striatal structures and abnormal movements in high-risk populations. Thirty participants with a prodromal syndrome were rated for dyskinetic movements and underwent structural magnetic resonance imaging (MRI). Volumes of striatal brain structures were delineated. Elevated hyperkinetic movements were found to be associated with smaller putamen and results were replicated in the antipsychotic naïve portion of the sample. Participants who converted over a 2-year follow-up period showed significantly smaller striatal volumes and a trend towards elevated dyskinetic movements, relative to those who did not convert. Movement abnormalities may reflect a striatal pathology that is present before formal psychosis onset, and potentially reflective of a heightened vulnerability for conversion.

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Striatal volumes and dyskinetic movements in youth at high-risk for psychosis

Abstract

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Keywords

ASJC Scopus subject areas

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