TY - JOUR
T1 - Stromal derived growth factor-1 (CXCL12) modulates synaptic transmission to immature neurons during post-ischemic cerebral repair
AU - Ardelt, Agnieszka A.
AU - Bhattacharyya, Bula J.
AU - Belmadani, Abdelhak
AU - Ren, Dongun
AU - Miller, Richard J.
PY - 2013/10
Y1 - 2013/10
N2 - In response to ischemic injury, the brain mounts a repair process involving the development of new neurons, oligodendrocytes, and astrocytes. However, the manner in which new neurons integrate into existing brain circuitry is not well understood. Here we observed that during the four weeks after transient middle cerebral artery occlusion (MCAO), doublecortin (DCX)-expressing neural progenitors originating in the subventricular zone (SVZ) were present in the ischemic lesion borderzone, where they received γ-aminobutyric acid (GABA) inputs, a feature that is common to newly developing neurons. The chemokine stromal derived factor-1 (SDF-1 or CXCL12) was enriched in lesional endothelial and microglial cells for up to four weeks after transient MCAO, and application of SDF-1 to acute brain slices enhanced GABAergic inputs to the new neurons. These observations suggest that SDF-1 is in a position to coordinate neovascularization and neurogenesis during the repair process after cerebral ischemia-reperfusion.
AB - In response to ischemic injury, the brain mounts a repair process involving the development of new neurons, oligodendrocytes, and astrocytes. However, the manner in which new neurons integrate into existing brain circuitry is not well understood. Here we observed that during the four weeks after transient middle cerebral artery occlusion (MCAO), doublecortin (DCX)-expressing neural progenitors originating in the subventricular zone (SVZ) were present in the ischemic lesion borderzone, where they received γ-aminobutyric acid (GABA) inputs, a feature that is common to newly developing neurons. The chemokine stromal derived factor-1 (SDF-1 or CXCL12) was enriched in lesional endothelial and microglial cells for up to four weeks after transient MCAO, and application of SDF-1 to acute brain slices enhanced GABAergic inputs to the new neurons. These observations suggest that SDF-1 is in a position to coordinate neovascularization and neurogenesis during the repair process after cerebral ischemia-reperfusion.
KW - Animal models
KW - Brain ischemia
KW - Chemokines
KW - Electrophysiology
KW - Neuroregeneration
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UR - http://www.scopus.com/inward/citedby.url?scp=84880379485&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2013.06.017
DO - 10.1016/j.expneurol.2013.06.017
M3 - Article
C2 - 23811016
AN - SCOPUS:84880379485
VL - 248
SP - 246
EP - 253
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
ER -