Stromal derived growth factor-1 (CXCL12) modulates synaptic transmission to immature neurons during post-ischemic cerebral repair

Agnieszka A. Ardelt*, Bula J. Bhattacharyya, Abdelhak Belmadani, Dongun Ren, Richard J. Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

In response to ischemic injury, the brain mounts a repair process involving the development of new neurons, oligodendrocytes, and astrocytes. However, the manner in which new neurons integrate into existing brain circuitry is not well understood. Here we observed that during the four weeks after transient middle cerebral artery occlusion (MCAO), doublecortin (DCX)-expressing neural progenitors originating in the subventricular zone (SVZ) were present in the ischemic lesion borderzone, where they received γ-aminobutyric acid (GABA) inputs, a feature that is common to newly developing neurons. The chemokine stromal derived factor-1 (SDF-1 or CXCL12) was enriched in lesional endothelial and microglial cells for up to four weeks after transient MCAO, and application of SDF-1 to acute brain slices enhanced GABAergic inputs to the new neurons. These observations suggest that SDF-1 is in a position to coordinate neovascularization and neurogenesis during the repair process after cerebral ischemia-reperfusion.

Original languageEnglish (US)
Pages (from-to)246-253
Number of pages8
JournalExperimental Neurology
Volume248
DOIs
StatePublished - Oct 2013

Keywords

  • Animal models
  • Brain ischemia
  • Chemokines
  • Electrophysiology
  • Neuroregeneration

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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