Stromal fibroblasts in cancer initiation and progression

Neil A. Bhowmick*, Eric G. Neilson, Harold L. Moses

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1661 Scopus citations

Abstract

It is widely accepted that the development of carcinoma - the most common form of human cancer - is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.

Original languageEnglish (US)
Pages (from-to)332-337
Number of pages6
JournalNature
Volume432
Issue number7015
DOIs
StatePublished - Nov 18 2004

ASJC Scopus subject areas

  • General

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