Stromal fibroblasts in cancer initiation and progression

Neil A. Bhowmick; Eric G. Neilson; Harold L. Moses

doi:10.1038/nature03096

Stromal fibroblasts in cancer initiation and progression

Neil A. Bhowmick^*, Eric G. Neilson, Harold L. Moses

^*Corresponding author for this work

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Research output: Contribution to journal › Review article › peer-review

1828 Scopus citations

Abstract

It is widely accepted that the development of carcinoma - the most common form of human cancer - is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.

Original language	English (US)
Pages (from-to)	332-337
Number of pages	6
Journal	Nature
Volume	432
Issue number	7015
DOIs	https://doi.org/10.1038/nature03096
State	Published - Nov 18 2004

ASJC Scopus subject areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nature03096

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title = "Stromal fibroblasts in cancer initiation and progression",

abstract = "It is widely accepted that the development of carcinoma - the most common form of human cancer - is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.",

author = "Bhowmick, {Neil A.} and Neilson, {Eric G.} and Moses, {Harold L.}",

note = "Funding Information: Acknowledgements This work was supported by a DOD USAMRMC grant (N.A.B.), NIH grants (H.L.M), and a Vanderbilt-Ingram Cancer Center Support Grant. We thank J. Pietenpol and S. Hayward for critical review of the manuscript and helpful advice.",

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AU - Bhowmick, Neil A.

AU - Neilson, Eric G.

AU - Moses, Harold L.

N1 - Funding Information: Acknowledgements This work was supported by a DOD USAMRMC grant (N.A.B.), NIH grants (H.L.M), and a Vanderbilt-Ingram Cancer Center Support Grant. We thank J. Pietenpol and S. Hayward for critical review of the manuscript and helpful advice.

PY - 2004/11/18

Y1 - 2004/11/18

N2 - It is widely accepted that the development of carcinoma - the most common form of human cancer - is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.

AB - It is widely accepted that the development of carcinoma - the most common form of human cancer - is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.

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UR - http://www.scopus.com/inward/citedby.url?scp=9244227134&partnerID=8YFLogxK

U2 - 10.1038/nature03096

DO - 10.1038/nature03096

M3 - Review article

C2 - 15549095

AN - SCOPUS:9244227134

SN - 0028-0836

VL - 432

SP - 332

EP - 337

JO - Nature

JF - Nature

IS - 7015

ER -

Stromal fibroblasts in cancer initiation and progression

Abstract

ASJC Scopus subject areas

UN SDGs

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