Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblings

Michael P. Harms, Lei Wang, Carolina Campanella, Kristina Aldridge, Amanda J. Moffitt, John Kuelper, J. Tilak Ratnanather, Michael L. Miller, Deanna M. Barch, John G. Csernansky

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Background: The relatives of individuals with schizophrenia exhibit deficits of overall frontal lobe volume, consistent with a genetic contribution to these deficits. Aims: To quantify the structure of gyral-defined subregions of prefrontal cortex in individuals with schizophrenia and their siblings. Method: Grey matter volume, cortical thickness, and surface area of the superior, middle and inferior frontal gyri were measured in participants with schizophrenia and their unaffected (non-psychotic) siblings (n=26 pairs), and controls and their siblings (n=40 pairs). Results: Grey matter volume was reduced in the middle and inferior frontal gyri of individuals with schizophrenia, relative to controls. However, only inferior frontal gyrus volume was also reduced in the unaffected siblings of those with schizophrenia, yielding a volume intermediate between their affected siblings and controls. Conclusions: The structure of subregions of the prefrontal cortex may be differentially influenced by genetic factors in schizophrenia, with inferior frontal gyrus volume being most related to familial risk.

Original languageEnglish (US)
Pages (from-to)150-157
Number of pages8
JournalBritish Journal of Psychiatry
Volume196
Issue number2
DOIs
StatePublished - Feb 2010

ASJC Scopus subject areas

  • Psychiatry and Mental health

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