Structural and biological studies on bacterial nitric oxide synthase inhibitors

Jeffrey K. Holden, Huiying Li, Qing Jing, Soosung Kang, Jerry Richo, Richard B. Silverman*, Thomas L. Poulos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Nitric oxide (NO) produced by bacterial NOS functions as a cytoprotective agent against oxidative stress in Staphylococcus aureus, Bacillus anthracis, and Bacillus subtilis. The screening of several NOS-selective inhibitors uncovered two inhibitors with potential antimicrobial properties. These two compounds impede the growth of B. subtilis under oxidative stress, and crystal structures show that each compound exhibits a unique binding mode. Both compounds serve as excellent leads for the future development of antimicrobials against bacterial NOS-containing bacteria.

Original languageEnglish (US)
Pages (from-to)18127-18131
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number45
StatePublished - Nov 5 2013


  • Antibiotics
  • Crystallography

ASJC Scopus subject areas

  • General


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