Structural and biological studies on bacterial nitric oxide synthase inhibitors

Jeffrey K. Holden, Huiying Li, Qing Jing, Soosung Kang, Jerry Richo, Richard B. Silverman*, Thomas L. Poulos

*Corresponding author for this work

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Nitric oxide (NO) produced by bacterial NOS functions as a cytoprotective agent against oxidative stress in Staphylococcus aureus, Bacillus anthracis, and Bacillus subtilis. The screening of several NOS-selective inhibitors uncovered two inhibitors with potential antimicrobial properties. These two compounds impede the growth of B. subtilis under oxidative stress, and crystal structures show that each compound exhibits a unique binding mode. Both compounds serve as excellent leads for the future development of antimicrobials against bacterial NOS-containing bacteria.

Original languageEnglish (US)
Pages (from-to)18127-18131
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number45
DOIs
StatePublished - Nov 5 2013

Keywords

  • Antibiotics
  • Crystallography

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Structural and biological studies on bacterial nitric oxide synthase inhibitors'. Together they form a unique fingerprint.

  • Cite this