Structural and Functional Imaging of the Human Olfactory System

Jay A. Gottfried*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

21 Scopus citations


New imaging approaches have induced a paradigm shift from the "where" to the "how" of odor information processing, providing novel mechanistic insights into the structural and functional organization of human olfaction. Work in patient populations has helped inform basic understanding of the human olfactory system, and translational studies have identified putative imaging biomarkers to optimize medical diagnostic decisions. This chapter surveys human olfactory imaging from its historical beginnings up through 2012. It briefly reviews the principles and methodology of magnetic resonance imaging (MRI) scanning. Finally, it discusses some of the key functions and mechanisms of the human olfactory system that have been established using both functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) methods, with an emphasis on studies in which the neural data are closely linked to specific olfactory perceptual or cognitive states.

Original languageEnglish (US)
Title of host publicationHandbook of Olfaction and Gustation
Subtitle of host publicationThird Edition
PublisherWiley Blackwell
Number of pages26
ISBN (Electronic)9781118971758
ISBN (Print)9781118139226
StatePublished - Jun 4 2015


  • Functional magnetic resonance imaging (fMRI)
  • Human olfactory imaging
  • Human olfactory system
  • Imaging biomarkers
  • Odor information processing
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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