Structural and mechanistic insights into methane oxidation by particulate methane monooxygenase

Ramakrishnan Balasubramanian, Amy C. Rosenzweig*

*Corresponding author for this work

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

Particulate methane monooxygense (pMMO) is an integral membrane copper-containing enzyme that converts methane to methanol. Knowledge of how pMMO selectively oxidizes methane under ambient conditions could impact the development of new catalysts. The crystal structure of Methylococcus capsulatus (Bath) pMMO reveals the composition and location of three metal centers. Spectroscopic data provide insight into the coordination environments and oxidation states of these metal centers. These results, combined with computational studies and comparisons to relevant systems, are discussed in the context of identifying the most likely site for O2 activation.

Original languageEnglish (US)
Pages (from-to)573-580
Number of pages8
JournalAccounts of chemical research
Volume40
Issue number7
DOIs
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Chemistry(all)

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