@article{a09fe5f0c25b4eb98a06bb6ac05cd0ff,
title = "Structural anomalies of the cervix and vagina in women enrolled in the Diethylstilbestrol Adenosis (DESAD) Project",
abstract = "Among women exposed in utero to diethylstilbestrol (DES) and enrolled in the Diethylstilbestrol Adenosis (DESAD) Project, structural anomalies of the cervix or vagina were found in 25% of the 1,655 subjects identified by review of prenatal records, 43% of the 800 who themselves requested entry into the project, and 49% of the 1,089 referred by physicians but in only 2% of the 963 control subjects. Among the 367 cases found by record review to have complete information on the DES exposure, multivariate analysis indicated close association of the anomalies with the gestational week of first exposure and the total dose. Also, the prevalence rate of the anomalies was lower among subjects who had been pregnant and higher among those with later age at menarche.",
author = "Jefferies, {J. A.} and Robboy, {S. J.} and O'Brien, {P. C.} and Bergstralh, {E. J.} and Labarthe, {D. R.} and Barnes, {A. B.} and Noller, {K. L.} and Hatab, {P. A.} and Kaufman, {R. H.} and Townsend, {D. E.}",
note = "Funding Information: Several previous articles have described numerous nonneoplastic uterine and vaginal anomalies found in young women who had been exposed in utero to diethylstilbestrol (DES).1-4 Reported here is our analysis of the types of gross anatomic anomalies of the cervix and upper vagina that were found on initial examination of 4,507 women enrolled through January 1, 1980, in the National Diethylstilbestrol Adenosis (DESAD) Project. This project was funded by the National Cancer Institute in 1974 to investigate the incidence and natural history of genital tract anomalies and clear cell adenocarcinoma in DES-exposed women. In our study, emphasis was placed on the types of changes found, correlation with the particular location in the genital tract, the effect of different total doses and schedules on the incidence of the abnormalities, and the natural history in comparison with experience among unexposed subjects (controls). Funding Information: From the Mayo Clinic, Harvard Medical School and Massachusetts General Hospital (Vincent Memorial Hospital), Baylor College of Medicine, University of Southern California, and Gundersen Clinic. The DESAD Project is supported by contracts from the Division of Cancer Control and Rehabilitation of the National Cancer Insti-tute, Contracts CN-45092, CN-45122, CN-45124, and CN-45127. Received for publication May 27, I982. Revised june 21, 1983. Accepted August 1, 1983. Reprint requests: DES Reprints, National Cancer Institute, Office of Cancer Communications, Bethesda, Maryland 20205.",
year = "1984",
doi = "10.1016/S0002-9378(84)80033-2",
language = "English (US)",
volume = "148",
pages = "59--66",
journal = "American journal of obstetrics and gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "1",
}