Structural basis for rational design of inhibitors targeting Trypanosoma cruzi Sterol 14α-demethylase: Two regions of the enzyme molecule potentiate its inhibition

Laura Friggeri, Tatiana Y. Hargrove, Girish Rachakonda, Amanda D. Williams, Zdzislaw Wawrzak, Roberto Di Santo, Daniela De Vita, Michael R. Waterman, Silvano Tortorella, Fernando Villalta, Galina I. Lepesheva*

*Corresponding author for this work

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    Immunology and Microbiology

    Pharmacology, Toxicology and Pharmaceutical Science