Structural basis of viral invasion: lessons from paramyxovirus F

Robert A. Lamb*, Theodore S. Jardetzky

*Corresponding author for this work

Research output: Contribution to journalReview article

198 Scopus citations

Abstract

The structures of glycoproteins that mediate enveloped virus entry into cells have revealed dramatic structural changes that accompany membrane fusion and provided mechanistic insights into this process. The group of class I viral fusion proteins includes the influenza hemagglutinin, paramyxovirus F, HIV env, and other mechanistically related fusogens, but these proteins are unrelated in sequence and exhibit clearly distinct structural features. Recently determined crystal structures of the paramyxovirus F protein in two conformations, representing pre-fusion and post-fusion states, reveal a novel protein architecture that undergoes large-scale, irreversible refolding during membrane fusion, extending our understanding of this diverse group of membrane fusion machines.

Original languageEnglish (US)
Pages (from-to)427-436
Number of pages10
JournalCurrent Opinion in Structural Biology
Volume17
Issue number4
DOIs
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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