Background: The relationship between structural and functional deficits in multiple sclerosis (MS) is unclear. Objective: This study explored structure-function relationships during the 5 years following a clinically isolated syndrome and their role in cognitive performance. Methods: Thirty-two patients were enrolled after their first neurological episode suggestive of MS and followed for 5 years, along with 10 matched healthy controls. We assessed structural (using diffusion tensor imaging) and functional (using resting-state functional magnetic resonance imaging (fMRI)) brain network metrics, clinical and cognitive scores at each follow-up visit. Structural–functional coupling, calculated as the correlation coefficient between strengths of structural and functional networks, was used to assess structure–function relationships. Results: Structural clustering coefficient was significantly increased after 5 years, whereas characteristic path length decreased. Structural connections decreased after 1 year and increased after 5 years. Functional connections and related path lengths were decreased after 5 years. Structural–functional coupling had increased significantly after 5 years. This structural–functional coupling was associated with cognitive and clinical evolution, with stronger coupling associated with a decline in both domains. Conclusion: Our findings provide novel biological evidence that MS leads to a more constrained anatomical-dependant functional connectivity. The collapse of this network seems to lead to both cognitive worsening and clinical disability.
|Original language||English (US)|
|Number of pages||9|
|Journal||Multiple Sclerosis Journal|
|State||Published - Apr 2021|
- Multiple sclerosis
- clinically isolated syndrome
- diffusion tensor imaging
- functional MRI
- graph theory
ASJC Scopus subject areas
- Clinical Neurology
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Structural constraints of functional connectivity drive cognitive impairment in the early stages of multiple sclerosis
Koubiyr, I. (Creator), Deloire, M. (Creator), Brochet, B. (Creator), Besson, P. A. (Creator), Charré-Morin, J. (Creator), Saubusse, A. (Creator), Tourdias, T. (Creator) & Ruet, A. (Creator), SAGE Journals, 2020
DOI: 10.25384/sage.c.5233278.v1, https://sage.figshare.com/collections/Structural_constraints_of_functional_connectivity_drive_cognitive_impairment_in_the_early_stages_of_multiple_sclerosis/5233278/1