Structural details of rat extraocular muscles and three-dimensional reconstruction of the rat inferior rectus muscle and muscle-pulley interface

Edward Felder; Sasha Bogdanovich; Neal A. Rubinstein; Tejvir S. Khurana

doi:10.1016/j.visres.2005.01.031

Structural details of rat extraocular muscles and three-dimensional reconstruction of the rat inferior rectus muscle and muscle-pulley interface

Edward Felder, Sasha Bogdanovich, Neal A. Rubinstein, Tejvir S. Khurana^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Light microscopy, electron microscopy and morphometry revealed structural details and allowed generation of a three-dimensional reconstruction of the pulley and muscle-pulley interface of extraocular muscle. The inferior rectus orbital layer was bifurcate in shape and extended anterior to the pulley. The putative pulley structure itself was asymmetric; loosely attached at the orbital aspect it adhered tightly to the global aspect of muscle. Orbital multiply innervated fiber proportion increased anterior to the pulley insertion site. Additionally longitudinal variation in juxtaposition of orbital and global layers was noted. These newly described structural details provide novel mechanistic insight for extraocular muscle function in rats.

Original language	English (US)
Pages (from-to)	1945-1955
Number of pages	11
Journal	Vision Research
Volume	45
Issue number	15
DOIs	https://doi.org/10.1016/j.visres.2005.01.031
State	Published - Jul 2005

Keywords

Eye movement
Eye muscle
Global layer
Multiply innervated fibers
Orbital layer
Pulley
Single innervated fibers
Three-dimensional reconstruction

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/j.visres.2005.01.031

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title = "Structural details of rat extraocular muscles and three-dimensional reconstruction of the rat inferior rectus muscle and muscle-pulley interface",

abstract = "Light microscopy, electron microscopy and morphometry revealed structural details and allowed generation of a three-dimensional reconstruction of the pulley and muscle-pulley interface of extraocular muscle. The inferior rectus orbital layer was bifurcate in shape and extended anterior to the pulley. The putative pulley structure itself was asymmetric; loosely attached at the orbital aspect it adhered tightly to the global aspect of muscle. Orbital multiply innervated fiber proportion increased anterior to the pulley insertion site. Additionally longitudinal variation in juxtaposition of orbital and global layers was noted. These newly described structural details provide novel mechanistic insight for extraocular muscle function in rats.",

keywords = "Eye movement, Eye muscle, Global layer, Multiply innervated fibers, Orbital layer, Pulley, Single innervated fibers, Three-dimensional reconstruction",

author = "Edward Felder and Sasha Bogdanovich and Rubinstein, {Neal A.} and Khurana, {Tejvir S.}",

note = "Funding Information: To Prof. Clara Franzini-Armstrong for invaluable guidance and generous use of imaging facilities. Supported by grants RO1 AR048871, R21 AR051696 and RO1 EY013862 (TSK); RO1 EY011779 (NAR); RO1 HL48093 (CFA), all from the National Institutes of Health, USA. Dr. Sasha Bogdanovich was funded by a grant from the Muscular Dystrophy Association, USA.",

year = "2005",

month = jul,

doi = "10.1016/j.visres.2005.01.031",

language = "English (US)",

volume = "45",

pages = "1945--1955",

journal = "Vision Research",

issn = "0042-6989",

publisher = "Elsevier Limited",

number = "15",

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TY - JOUR

T1 - Structural details of rat extraocular muscles and three-dimensional reconstruction of the rat inferior rectus muscle and muscle-pulley interface

AU - Felder, Edward

AU - Bogdanovich, Sasha

AU - Rubinstein, Neal A.

AU - Khurana, Tejvir S.

N1 - Funding Information: To Prof. Clara Franzini-Armstrong for invaluable guidance and generous use of imaging facilities. Supported by grants RO1 AR048871, R21 AR051696 and RO1 EY013862 (TSK); RO1 EY011779 (NAR); RO1 HL48093 (CFA), all from the National Institutes of Health, USA. Dr. Sasha Bogdanovich was funded by a grant from the Muscular Dystrophy Association, USA.

PY - 2005/7

Y1 - 2005/7

N2 - Light microscopy, electron microscopy and morphometry revealed structural details and allowed generation of a three-dimensional reconstruction of the pulley and muscle-pulley interface of extraocular muscle. The inferior rectus orbital layer was bifurcate in shape and extended anterior to the pulley. The putative pulley structure itself was asymmetric; loosely attached at the orbital aspect it adhered tightly to the global aspect of muscle. Orbital multiply innervated fiber proportion increased anterior to the pulley insertion site. Additionally longitudinal variation in juxtaposition of orbital and global layers was noted. These newly described structural details provide novel mechanistic insight for extraocular muscle function in rats.

AB - Light microscopy, electron microscopy and morphometry revealed structural details and allowed generation of a three-dimensional reconstruction of the pulley and muscle-pulley interface of extraocular muscle. The inferior rectus orbital layer was bifurcate in shape and extended anterior to the pulley. The putative pulley structure itself was asymmetric; loosely attached at the orbital aspect it adhered tightly to the global aspect of muscle. Orbital multiply innervated fiber proportion increased anterior to the pulley insertion site. Additionally longitudinal variation in juxtaposition of orbital and global layers was noted. These newly described structural details provide novel mechanistic insight for extraocular muscle function in rats.

KW - Eye movement

KW - Eye muscle

KW - Global layer

KW - Multiply innervated fibers

KW - Orbital layer

KW - Pulley

KW - Single innervated fibers

KW - Three-dimensional reconstruction

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SN - 0042-6989

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SP - 1945

EP - 1955

JO - Vision Research

JF - Vision Research

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ER -

Structural details of rat extraocular muscles and three-dimensional reconstruction of the rat inferior rectus muscle and muscle-pulley interface

Abstract

Keywords

ASJC Scopus subject areas

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