Structural determinants of the mechanical stability of α-Catenin

Jing Li, Jillian Newhall, Noboru Ishiyama, Cara Gottardi, Mitsuhiko Ikura, Deborah E. Leckband*, Emad Tajkhorshid

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background: We investigated how α-catenin transduces force at cell-to-cell adhesions. Results: Molecular dynamics simulations identified structural features contributing to α-catenin stability and its deformation under applied force. Conclusion: A cooperative network of salt bridges in α-catenin regulates both α-catenin stability and how it unfolds under force. Significance: These findings reveal the molecular basis of experimental observations and the impact of reported cancer-linked α-catenin mutants.

Original languageEnglish (US)
Pages (from-to)18890-18903
Number of pages14
JournalJournal of Biological Chemistry
Issue number31
StatePublished - Jul 31 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Cell Biology


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