Abstract
The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes. A high frequency of mutations has been found in SWI/SNF family subunits by exome sequencing in human cancer, and multiple studies support its role in tumor suppression. Recent structural studies of yeast SWI/SNF and its human homolog, BAF (BRG1/BRM associated factor), have provided a model for their complex assembly and their interaction with nucleosomal substrates, revealing the molecular function of individual subunits as well as the potential impact of cancer‐associated mutations on the remodeling function. Here we review the structural conservation between yeast SWI/SNF and BAF and examine the role of highly mutated subunits within the BAF complex.
| Original language | English (US) |
|---|---|
| Article number | 146 |
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Biology |
| Volume | 9 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2020 |
Funding
Funding: This work was supported by R01GM135651, P01CA092584, and U54CA193419 from NIH. A. A. Reyes is supported by the Molecular Biophysics Training Program from NIGMS/NIH (5T32 GM008382).
Keywords
- BAF complex
- Cancer
- Chromatin remodeling
- Cryo‐EM
- SWI/SNF complex
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology
- General Agricultural and Biological Sciences
