Structural insights into the evolutionarily conserved BAF chromatin remodeling complex

Ryan D. Marcum; Alexis A. Reyes; Yuan He

doi:10.3390/biology9070146

Structural insights into the evolutionarily conserved BAF chromatin remodeling complex

Ryan D. Marcum, Alexis A. Reyes, Yuan He^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Review article › peer-review

Abstract

The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes. A high frequency of mutations has been found in SWI/SNF family subunits by exome sequencing in human cancer, and multiple studies support its role in tumor suppression. Recent structural studies of yeast SWI/SNF and its human homolog, BAF (BRG1/BRM associated factor), have provided a model for their complex assembly and their interaction with nucleosomal substrates, revealing the molecular function of individual subunits as well as the potential impact of cancer‐associated mutations on the remodeling function. Here we review the structural conservation between yeast SWI/SNF and BAF and examine the role of highly mutated subunits within the BAF complex.

Original language	English (US)
Article number	146
Pages (from-to)	1-9
Number of pages	9
Journal	Biology
Volume	9
Issue number	7
DOIs	https://doi.org/10.3390/biology9070146
State	Published - Jul 2020

Keywords

BAF complex
Cancer
Chromatin remodeling
Cryo‐EM
SWI/SNF complex

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)

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title = "Structural insights into the evolutionarily conserved BAF chromatin remodeling complex",

abstract = "The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes. A high frequency of mutations has been found in SWI/SNF family subunits by exome sequencing in human cancer, and multiple studies support its role in tumor suppression. Recent structural studies of yeast SWI/SNF and its human homolog, BAF (BRG1/BRM associated factor), have provided a model for their complex assembly and their interaction with nucleosomal substrates, revealing the molecular function of individual subunits as well as the potential impact of cancer‐associated mutations on the remodeling function. Here we review the structural conservation between yeast SWI/SNF and BAF and examine the role of highly mutated subunits within the BAF complex.",

keywords = "BAF complex, Cancer, Chromatin remodeling, Cryo‐EM, SWI/SNF complex",

author = "Marcum, {Ryan D.} and Reyes, {Alexis A.} and Yuan He",

note = "Funding Information: Funding: This work was supported by R01GM135651, P01CA092584, and U54CA193419 from NIH. A. A. Reyes is supported by the Molecular Biophysics Training Program from NIGMS/NIH (5T32 GM008382). Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = jul,

doi = "10.3390/biology9070146",

language = "English (US)",

volume = "9",

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AU - Marcum, Ryan D.

AU - Reyes, Alexis A.

AU - He, Yuan

N1 - Funding Information: Funding: This work was supported by R01GM135651, P01CA092584, and U54CA193419 from NIH. A. A. Reyes is supported by the Molecular Biophysics Training Program from NIGMS/NIH (5T32 GM008382). Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2020/7

Y1 - 2020/7

N2 - The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes. A high frequency of mutations has been found in SWI/SNF family subunits by exome sequencing in human cancer, and multiple studies support its role in tumor suppression. Recent structural studies of yeast SWI/SNF and its human homolog, BAF (BRG1/BRM associated factor), have provided a model for their complex assembly and their interaction with nucleosomal substrates, revealing the molecular function of individual subunits as well as the potential impact of cancer‐associated mutations on the remodeling function. Here we review the structural conservation between yeast SWI/SNF and BAF and examine the role of highly mutated subunits within the BAF complex.

AB - The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes. A high frequency of mutations has been found in SWI/SNF family subunits by exome sequencing in human cancer, and multiple studies support its role in tumor suppression. Recent structural studies of yeast SWI/SNF and its human homolog, BAF (BRG1/BRM associated factor), have provided a model for their complex assembly and their interaction with nucleosomal substrates, revealing the molecular function of individual subunits as well as the potential impact of cancer‐associated mutations on the remodeling function. Here we review the structural conservation between yeast SWI/SNF and BAF and examine the role of highly mutated subunits within the BAF complex.

KW - BAF complex

KW - Cancer

KW - Chromatin remodeling

KW - Cryo‐EM

KW - SWI/SNF complex

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Structural insights into the evolutionarily conserved BAF chromatin remodeling complex

Abstract

Keywords

ASJC Scopus subject areas

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