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Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase
Hai Yuan,
Richard B. Silverman
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Corresponding author for this work
Chemistry
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Article
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peer-review
22
Scopus citations
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Dive into the research topics of 'Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase'. Together they form a unique fingerprint.
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Keyphrases
Amino
100%
Structural Modification
100%
GABA-transaminase
100%
Irreversible Inhibitor
100%
Lipophilic
60%
Vigabatrin
60%
Inactivator
40%
Convulsion
40%
Epilepsy
20%
Isostere
20%
Inhibitory Neurotransmitter
20%
Brain Levels
20%
Aminobutyric Acid
20%
Reversible Inhibition
20%
Carboxylic Acids
20%
Compound 3
20%
Tetrazole
20%
Dichloromethylene
20%
Enhanced Bioavailability
20%
ClogP
20%
Pharmacology, Toxicology and Pharmaceutical Science
4 Aminobutyrate Aminotransferase
100%
4 Aminobutyric Acid
60%
Vigabatrin
60%
Carboxylate
20%
Neurotransmitter
20%
Tetrazole Derivative
20%
Bioavailability
20%