TY - JOUR
T1 - Structural polymorphism of the actin-espin system
T2 - A prototypical system of filaments and linkers in stereocilia
AU - Purdy, Kirstin R.
AU - Bartles, James R.
AU - Wong, Gerard C.L.
PY - 2007/1/2
Y1 - 2007/1/2
N2 - We examine the interaction between cytoskeletal F-actin and espin 3A, a prototypical actin bundling protein found in sensory cell microvilli, including ear cell stereocilia. Espin induces twist distortions in F-actin as well as facilitates bundle formation. Mutations in one of the two F-actin binding sites of espin, which have been implicated in deafness, can tune espin-actin interactions and radically transform the system's phase behavior. These results are compared to recent theoretical work on the general phase behavior linker-rod systems.
AB - We examine the interaction between cytoskeletal F-actin and espin 3A, a prototypical actin bundling protein found in sensory cell microvilli, including ear cell stereocilia. Espin induces twist distortions in F-actin as well as facilitates bundle formation. Mutations in one of the two F-actin binding sites of espin, which have been implicated in deafness, can tune espin-actin interactions and radically transform the system's phase behavior. These results are compared to recent theoretical work on the general phase behavior linker-rod systems.
UR - http://www.scopus.com/inward/record.url?scp=33846794288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846794288&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.98.058105
DO - 10.1103/PhysRevLett.98.058105
M3 - Article
C2 - 17358907
AN - SCOPUS:33846794288
SN - 0031-9007
VL - 98
JO - Physical review letters
JF - Physical review letters
IS - 5
M1 - 058105
ER -